Kidney disease: Senescent cell burden is reduced in humans by senolytic drugs

In a small safety and feasibility clinical trial, Mayo Clinic researchers have demonstrated for the first time that senescent cells can be removed from the body using drugs termed “senolytics.” The result was verified not only in analysis of blood but also in changes in skin and fat tissue senescent cell abundance. The findings appear in the journal EBioMedicine. This […]

Read more

Stem cell researchers reactivate ‘back-up genes’ in the lab: Researchers in Belgium present new findings on X chromosome reactivation

Vincent Pasque and his team at KU Leuven have unravelled parts of a mechanism that may one day help to treat Rett syndrome and other genetic disorders linked to the X chromosome. Women and most female mammals have two X chromosomes, but only one of these is active in any given cell. This active X chromosome is selected through a […]

Read more

Cellular processes controlling the formation of lymphatic valves: Targeting VE-cadherin signaling pathways holds promise for treating lymphedema’s debilitative swelling

Lymphedema, resulting from a damaged lymphatic system, can be a debilitating disease in which excess protein-rich fluid (lymph) collects in soft tissues and causes swelling — most often in the arms or legs. Symptom severity varies, but the chronic swelling can lead to pain, thickened skin, disfigurement, loss of mobility in affected limbs, and recurrent infections. While lymphedema can be […]

Read more

Single protein plays important dual transport roles in the brain

Just as a packaging breakdown can hamstring delivery of cables, switches and connectors to a house under construction, removing a protein from neurons can block the “shipment” of proteins to developing axons. Axons are the telephone wires of the nervous system. They convey information to dendrites on other nerve cells, in a processing network of phenomenal complexity that is the […]

Read more

Scientists reverse aging process in rat brain stem cells

New research, published today in Nature, reveals how increasing brain stiffness as we age causes brain stem cell dysfunction, and demonstrates new ways to reverse older stem cells to a younger, healthier state. The results have far reaching implications for how we understand the ageing process, and how we might develop much-needed treatments for age-related brain diseases. As our bodies […]

Read more

A simpler way to choose the sex of offspring by separating X and Y sperm: Differential gene activity by the two sex chromosomes allows X-bearing sperm to be slowed down

A simple, reversible chemical treatment can segregate X-bearing sperm from Y-bearing sperm, allowing dramatic alteration of the normal 50/50 male/female offspring ratio, according to a new study by Masayuki Shimada and colleagues at Hiroshima University, published on August 13 in the open-access journal PLOS Biology. The study was performed in mice, but the technique is likely to be widely applicable […]

Read more

Human cells assembling into fractal-like clusters

Tree-like branching structures are everywhere in the human body, from the bronchial system in the lungs to the spidering capillaries that supply blood to the extremities. Researchers have long worked to understand the cellular signaling needed to build these intricate structures, but new research suggests that simple physics may play an underappreciated role. The research, published in the Proceedings of […]

Read more

Better tools, better cancer immunotherapy

In the journal Science Immunology, researchers from DTU Health Technology and Jacobs University in Bremen have just published their cutting-edge research demonstrating advancement in detection of a certain type of immune cells, called T cells. Improved detection of T cells have several therapeutic implications. For example, in cancer immunotherapy (a therapeutic approach that engage patients own immune cells) characterization of […]

Read more

Study links progenitor cells to age-related prostate growth: As the organ enlarges, the risk for cancer and other diseases increases

The prostates of older mice contain more luminal progenitor cells — cells capable of generating new prostate tissue — than the prostates of younger mice, UCLA researchers have discovered. The observation, published in Cell Reports, helps explain why, as people age, the prostate tends to grow, leading to an increased risk for prostate cancer and other conditions. “Understanding what’s causing […]

Read more

New insight into microRNA function can give gene therapy a boost

Scientists at the University of Eastern Finland and the University of Oxford have shown that small RNA molecules occurring naturally in cells, i.e. microRNAs, are also abundant in cell nuclei. Previously, microRNAs were mainly thought to be found in cytoplasm. The scientists also discovered that microRNA concentrations in cell nuclei change as a result of hypoxia. The findings strongly suggest […]

Read more
1 2 3 4