Drug combination shows promise in preclinical models of triple negative breast cancer

Tumor volume in a preclinical model of triple negative breast cancer (TNBC) was reduced four times more when an experimental polo-like kinase 1 (PLK1) inhibitor was combined with a standard-of-care chemotherapeutic agent than when the agent was used alone. Hollings Cancer Center scientists at the Medical University of South Carolina reported these findings in PLOS ONE. TNBC disproportionately affects African […]

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Omega-3 shows protection against heart disease-related death, without prostate cancer risk

Should you take omega-3 pills? Or try to have two to servings of omega-3 rich fish a week, as the American Heart Association recommends? It may seem a bit murky if you follow headlines about nutrition and health. That’s why researchers at the Intermountain Healthcare Heart Institute continue to research the potential benefits and risks of this popular supplement, especially […]

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Study shows biomarker accurately diagnoses deadly infant disease

A diagnostic study of 136 premature infants found that a protein involved in managing harmful bacteria in the human intestine is a reliable biomarker for the noninvasive detection of necrotizing enterocolitis (NEC). Led by researchers and clinicians at LSU Health New Orleans School of Medicine, this is one of the largest prospective clinical studies in premature infants yet. Results of […]

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Long-acting injectable multi-drug implant shows promise for HIV prevention and treatment

A new study published today in Nature Communications shows a promising alternative for those who have to take a daily pill regimen. Targeting HIV treatment and prevention, researchers across multiple departments at the University of North Carolina at Chapel Hill collaborated on a seven-year study in animals to make a better injectable drug implant that can combine multiple drugs and […]

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Study shows rate of extreme inbreeding in the U.K. and possible health impacts of it

A team of researchers has found a way to gauge the rate of extreme inbreeding (EI) in the U.K. and its possible health repercussions. In their paper published in the journal Nature Communications, the group describes their study of data from the U.K. Biobank and what they found. The researchers began their study by noting that not a lot of […]

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Virtual treasure hunt shows brain maps time sequence of memories

People have little difficulty remembering the chronology of events, determining how much time passed between two events, and which one occurred first. Apparently, memories of events in the brain are linked when they occur closely together. Using an experiment that combines virtual reality and brain scan technology, Jacob Bellmund and Christian Doeller from the Max Planck Institute for Human Cognitive […]

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Targeting a blood stem cell subset shows lasting, therapeutically relevant gene editing

In a paper published in the July 31 issue of Science Translational Medicine, researchers at Fred Hutchinson Cancer Research Center used CRISPR-Cas9 to edit long-lived blood stem cells to reverse the clinical symptoms observed with several blood disorders, including sickle cell disease and beta-thalassemia. It’s the first time that scientists have specifically edited the genetic makeup of a specialized subset […]

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Data shows flood of opioids across US, many of them generics

The maker of OxyContin has been cast as the chief villain in the nation’s opioid crisis. But newly released government figures suggest Purdue Pharma had plenty of help in flooding the U.S. with billions of pills even as overdose deaths were accelerating. Records kept by the federal Drug Enforcement Administration show that 76 billion oxycodone and hydrocodone pills—the vast majority […]

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Study shows widespread global implementation of WHO’s ‘Treat All’ HIV recommendation

A new study published in the Journal of the International AIDS Society shows that the World Health Organization’s (WHO) 2015 recommendation for immediate treatment of all people living with HIV has become the standard of care across HIV clinics in countries around the world. While most countries have adopted the WHO’s “Treat All” recommendation, the extent to which these guidelines […]

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New evidence shows cytotoxic T cells can identify, invade, and destroy targets of large mass like T. gondii tissue cysts

CD8+ cytotoxic T lymphocytes can kill host cells infected with various microorganisms as well as single individual cancer cells through direct cell-to-cell contact, but their ability to destroy a target of large mass remains unexplored. A study in The American Journal of Pathology provided novel evidence on the capability of the immune system to eliminate large parasite-filled cysts associated with […]

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