Snout dated: Slow-evolving elephant shark offers new insights into human physiology

The mineralocortoid receptor (MR) regulates water and sodium transport throughout cells and tissues, which is critical for controlling blood pressure and so, not surprisingly, the MR is common to all vertebrate animals. Aldosterone, which is a physiological steroid for land vertebrate MRs, evolved in lungfish (forerunners of land vertebrates), suggesting that the evolution of aldosterone was important in the conquest […]

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