Pediatricians have role to play in addressing racism

(HealthDay)—Pediatricians should play a role in advocating to redress biases and inequalities in the health system and other systems, according to a policy statement published online July 29 in Pediatrics. Maria Trent, M.D., M.P.H., from Johns Hopkins University in Baltimore, and colleagues address the impact of racism on child and adolescent health. The authors note that pediatricians and other child […]

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SIRT1 plays key role in chronic myeloid leukemia to aid persistence of leukemic stem cells

Patients with chronic myeloid leukemia can be treated with tyrosine kinase inhibitors. While these effective drugs lead to deep remission and prolonged survival, primitive leukemia stem cells resist elimination during the remission and persist as a major barrier to cure. As a result, the majority of patients with chronic myeloid leukemia, or CML, require indefinite inhibitor treatment to prevent disease […]

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Scientists define the role for a rare, influential set of bone marrow cells

Researchers have defined the roles of various cells in the bone marrow that are thought to control the fate of the nearly half million blood cells that develop there each day. Scientists at NYU School of Medicine behind the new work say little had been known about the fraction of cells examined in the study, the “microenvironment” that makes up […]

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Do minerals play a role in development of multiple sclerosis?

Some studies have suggested that minerals such as zinc and iron may play a role in how multiple sclerosis (MS) progresses, once people have been diagnosed with it. But little was known about whether zinc, iron and other minerals play a role in the development of the disease. A new study shows no link between dietary intake of several minerals […]

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Retinal prion disease study redefines role for brain cells

National Institutes of Health scientists studying the progression of inherited and infectious eye diseases that can cause blindness have found that microglia, a type of nervous system cell suspected to cause retinal damage, surprisingly had no damaging role during prion disease in mice. In contrast, the study findings indicated that microglia might delay disease progression. The discovery could apply to […]

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Scientists find first evidence for necessary role of the human hippocampus in planning

A team of scientists reports finding the first evidence that the human hippocampus is necessary for future planning. Its findings, published in the journal Neuron, link its long-established role in memory with our ability to use our knowledge to map out the future effects of our actions. The results have implications for the way we think about afflictions that affect […]

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Adipocyte glucocorticoid receptors play a role in developing steroid diabetes

Steroids are used for treating various diseases such as allergic disorders, but they occasionally cause adverse effects, such as steroid diabetes and other metabolic disturbances. Since steroids act throughout the body, how these adverse effects are caused and by which organ are not well understood. Researchers at Osaka University focused on glucocorticoid receptors (GRs), the receptors for the body’s endogenous […]

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Role of PCSK9 inhibitors in high risk patients with dyslipidemia

Familial hypercholesterolemia (FH) is an inherited autosomal dominant disorder which is characterized by substantially increased Low-Density Lipoprotein Cholesterol (LDL-C) levels. Timely reduction of LDL-C is of paramount importance to ameliorate the risk for CV disease as patients with FH have a significantly higher risk for Cardiovascular (CV) events. Pro-protein Convertase Subtilisin/Kexin type 9 (PCSK9) inhibitors have emerged as a very […]

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New research questions role of gut parasite in intestinal diseases such as irritable bowel syndrome

New University of Kent-led research on the way a common gut parasite behaves could help lead to a better understanding of its role in the development of intestinal diseases such as irritable bowel syndrome. A team at the University of Kent, working with researchers from other universities, found that the microbe Blastocystis, commonly found in the guts of both humans […]

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Dad’s Age May Play Role in Pregnancy Outcomes

THURSDAY, Nov. 1, 2018 — More men are delaying fatherhood, and new research suggests that might raise the risk of both birth complications and infant health problems. When new fathers are aged 45 or older, there’s an increased chance of preterm birth, infant seizures and even gestational diabetes in the mother, the study found. “When you think about fertility, don’t […]

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