Study identifies role of specific gene in hardening of blood vessel walls

Arterial wall calcification is the buildup of calcium in the blood vessel walls, which can often be a predictor of serious cardiovascular events like heart attacks and strokes. Scientists have long pointed to family history as one possible cause for this hardening of the arteries, but a new study published in Nature Genetics implicates a specific gene—HDAC9—in the calcification of […]

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Cell family trees tracked to discover their role in tissue scarring and liver disease

Researchers have discovered that a key cell type involved in liver injury and cancer consists of two cellular families with different origins and functions. The research by academics from the Universities of Edinburgh and Bristol and funded by the Wellcome Trust and Medical Research Council, is published today [Tuesday 15 October] in Nature Communications. The distinguishing feature of these families—whether […]

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Pediatricians have role to play in addressing racism

(HealthDay)—Pediatricians should play a role in advocating to redress biases and inequalities in the health system and other systems, according to a policy statement published online July 29 in Pediatrics. Maria Trent, M.D., M.P.H., from Johns Hopkins University in Baltimore, and colleagues address the impact of racism on child and adolescent health. The authors note that pediatricians and other child […]

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SIRT1 plays key role in chronic myeloid leukemia to aid persistence of leukemic stem cells

Patients with chronic myeloid leukemia can be treated with tyrosine kinase inhibitors. While these effective drugs lead to deep remission and prolonged survival, primitive leukemia stem cells resist elimination during the remission and persist as a major barrier to cure. As a result, the majority of patients with chronic myeloid leukemia, or CML, require indefinite inhibitor treatment to prevent disease […]

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Scientists define the role for a rare, influential set of bone marrow cells

Researchers have defined the roles of various cells in the bone marrow that are thought to control the fate of the nearly half million blood cells that develop there each day. Scientists at NYU School of Medicine behind the new work say little had been known about the fraction of cells examined in the study, the “microenvironment” that makes up […]

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Do minerals play a role in development of multiple sclerosis?

Some studies have suggested that minerals such as zinc and iron may play a role in how multiple sclerosis (MS) progresses, once people have been diagnosed with it. But little was known about whether zinc, iron and other minerals play a role in the development of the disease. A new study shows no link between dietary intake of several minerals […]

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Retinal prion disease study redefines role for brain cells

National Institutes of Health scientists studying the progression of inherited and infectious eye diseases that can cause blindness have found that microglia, a type of nervous system cell suspected to cause retinal damage, surprisingly had no damaging role during prion disease in mice. In contrast, the study findings indicated that microglia might delay disease progression. The discovery could apply to […]

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Scientists find first evidence for necessary role of the human hippocampus in planning

A team of scientists reports finding the first evidence that the human hippocampus is necessary for future planning. Its findings, published in the journal Neuron, link its long-established role in memory with our ability to use our knowledge to map out the future effects of our actions. The results have implications for the way we think about afflictions that affect […]

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Adipocyte glucocorticoid receptors play a role in developing steroid diabetes

Steroids are used for treating various diseases such as allergic disorders, but they occasionally cause adverse effects, such as steroid diabetes and other metabolic disturbances. Since steroids act throughout the body, how these adverse effects are caused and by which organ are not well understood. Researchers at Osaka University focused on glucocorticoid receptors (GRs), the receptors for the body’s endogenous […]

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Role of PCSK9 inhibitors in high risk patients with dyslipidemia

Familial hypercholesterolemia (FH) is an inherited autosomal dominant disorder which is characterized by substantially increased Low-Density Lipoprotein Cholesterol (LDL-C) levels. Timely reduction of LDL-C is of paramount importance to ameliorate the risk for CV disease as patients with FH have a significantly higher risk for Cardiovascular (CV) events. Pro-protein Convertase Subtilisin/Kexin type 9 (PCSK9) inhibitors have emerged as a very […]

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