Ketamine reverses neural changes underlying depression-related behaviors in mice: Study sheds light on the neural mechanisms underlying remission of depression

Researchers have identified ketamine-induced brain-related changes that are responsible for maintaining the remission of behaviors related to depression in mice — findings that may help researchers develop interventions that promote lasting remission of depression in humans. The study, funded by the National Institute of Mental Health (NIMH), part of the National Institutes of Health, appears in the journal Science. Major […]

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Psychiatry: Multigene test predicts depression risk

According to the World Health Organization, depression is now the leading cause of disability, globally affecting more than 300 million people worldwide. Depression is a condition that results from interactions between biological, psychological and social factors. Although depression can become manifest at any age, it often first emerges during adolescence. Identifying the risk factors for depression before clinically confounding symptoms […]

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Experiments with roundworms suggest alternatives for the treatment of schizophrenia: Researchers used C. elegans as an animal model to investigate the importance of certain human genes for the treatment of schizophrenia.

A group of Brazilian scientists have long conducted experiments with roundworms to investigate the role of schizophrenia-linked genes in patients’ response to antipsychotic drugs. The results obtained thus far point to new ways of understanding resistance to certain classes of medication. The studies are conducted by researchers in the Pharmacology Department of the Federal University of São Paulo’s Medical School […]

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Deep brain stimulation sites for OCD target distinct symptoms: Two DBS sites equally reduced OCD symptoms but improved distinct symptoms

Deep brain stimulation (DBS) reduces symptoms of severe obsessive-compulsive disorder (OCD) during stimulation of either the ventral capsule (VC) or anteromedial subthalamic nucleus (amSTN), according to a study in Biological Psychiatry. DBS of the regions reduced OCD symptoms to a similar extent, but produced distinct effects on specific symptoms — VC stimulation drastically improved mood, whereas amSTN stimulation in the […]

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Integrated therapy treating obesity and depression is effective

An intervention combining behavioral weight loss treatment and problem-solving therapy with as-needed antidepressant medication for participants with co-occurring obesity and depression improved weight loss and depressive symptoms compared with routine physician care, according to an article published in the Journal of the American Medical Association. Obesity and depression commonly occur together. Approximately 43 percent of adults with depression are obese, […]

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Neural processing with trauma and adversity interact to increase core symptom of PTSD

Lifetime adversity and increased neural processing during a traumatic event combine to increase the frequency of intrusive traumatic memories and the distress they cause, according to a new study in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. The increased neural processing was found in brain regions important for emotion and memory. The involuntary recollection of traumatic events is a core symptom […]

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How bad will my postpartum depression be in 12 months? ‘Game-changing’ study uses four factors to accurately predict severity, longevity of postpartum depression

A new Northwestern Medicine study was able to successfully predict if a new mother would experience worsening depressive symptoms over the first year after giving birth by identifying four maternal characteristics that put her at risk. Identifying these factors early in the postpartum period will allow mothers to seek treatment earlier and improve their chance of a full recovery, the […]

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Alcohol dependence, psychiatric disorders share genetic links: Key alcoholism gene influences how quickly body metabolizes alcohol

In the largest study of genetic factors linked to alcohol dependence, an international team of researchers identified a gene known to affect risk, and they determined that many other genes also contribute to risk for alcohol dependence to a lesser degree. In addition, the study linked genetic factors associated with alcohol dependence to other psychiatric disorders, such as depression, and […]

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How Can I Find the Best Psychiatrist?

According to the National Institute of Mental Health, nearly 1 in 5 U.S. adults lives with a mental illness.(Getty Images) The brain is an intricate organ, and with that complexity comes the possibility for things to go wrong. Although neurologists take care of certain aspects of the brain and diseases that begin there, there’s more to having a healthy brain […]

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