Mini-kidneys grown from stem cells provide new insights into kidney disease and potential therapies

An international team of researchers led by Nanyang Technological University, Singapore (NTU Singapore) has grown ‘miniature kidneys’ in the laboratory that could be used to better understand how kidney diseases develop in individual patients. The mini kidneys, known as kidney organoids, were grown outside the body from skin cells derived from a single patient who has polycystic kidney disease, one […]

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Computational model of a human kinase may provide insights for cancer treatment

Researchers have developed a computational model for human MEK1, a protein with potential as a drug target for a variety of human cancers. The initiation and progression of cancer cells occur when molecular signals involved in cellular proliferation go awry. MEK1 plays an essential role in signaling within both healthy and cancer cells. While much is known about the key […]

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Drug Repurposing May Provide More Psychiatric Tx Options

FRIDAY, Jan. 11, 2019 — Three classes of drugs hold potential as repurposed agents to treat patients with serious mental illness, according to a study published online Jan. 9 in JAMA Psychiatry. Joseph F. Hayes, Ph.D., from University College London, and colleagues evaluated the repurposing of hydroxylmethyl glutaryl coenzyme A reductase inhibitors (HMG-CoA RIs), L-type calcium channel (LTCC) antagonists, and […]

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Soil bacteria provide a promising E. coli treatment

E. coli, the notorious bug associated with severe food poisoning and usually caught from undercooked meat, is a common concern for anyone cooking over the festive period. While thoroughly cooking meat and washing vegetables and hands after food preparation can prevent E. coli infection, treatment for the severe stomach bug can be difficult, as antibiotics are known to make the […]

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