Drug combination shows promise in preclinical models of triple negative breast cancer

Tumor volume in a preclinical model of triple negative breast cancer (TNBC) was reduced four times more when an experimental polo-like kinase 1 (PLK1) inhibitor was combined with a standard-of-care chemotherapeutic agent than when the agent was used alone. Hollings Cancer Center scientists at the Medical University of South Carolina reported these findings in PLOS ONE. TNBC disproportionately affects African […]

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Long-acting injectable multi-drug implant shows promise for HIV prevention and treatment

A new study published today in Nature Communications shows a promising alternative for those who have to take a daily pill regimen. Targeting HIV treatment and prevention, researchers across multiple departments at the University of North Carolina at Chapel Hill collaborated on a seven-year study in animals to make a better injectable drug implant that can combine multiple drugs and […]

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Remedy for sleep disorders often superfluous or even risky

Consumer advocates: effect of the products against insomnia doubtful Million people in Germany suffer from sleep disorders. Too little sleep not only ensures that those Affected are during the day, mostly tired, but also is a risk to health. The use of over-the-counter remedies to promote better sleep, is not usually recommended nevertheless. Some of these drugs can even be […]

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Sutimlimab shows promise for hard-to-treat, rare blood disorder

In a first-in-human clinical trial reported today in Blood, the investigational drug sutimlimab appeared to be effective in treating cold agglutinin disease, a rare chronic blood disorder for which there are currently no approved treatments. Cold agglutinin disease is caused by a malfunction in the immune system that causes antibodies—components of the immune system that are produced in the blood […]

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