Ragweed compounds could protect nerve cells from Alzheimer’s

As spring arrives in the northern hemisphere, many people are cursing ragweed, a primary culprit in seasonal allergies. But scientists might have discovered a promising new use for some substances produced by the pesky weed. In ACS’ Journal of Natural Products, researchers have identified and characterized ragweed compounds that could help nerve cells survive in the presence of Alzheimer’s disease […]

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A deep-dive into the impact of arthritis drugs on gene expression: New analytical approach could serve as powerful tool to evaluate and compare treatments

A new computational framework has revealed key differences between four rheumatoid arthritis medications and their impact on biological pathways in mice. Niki Karagianni of Biomedcode Hellas SA, Greece, and colleagues present their new approach and findings in PLOS Computational Biology. People with rheumatoid arthritis often receive medications that target and inhibit Tumor-Necrosis Factor (TNF), a protein involved in the painful […]

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‘NarcoLogic’ computer model shows unintended consequences of cocaine interdiction

Efforts to curtail the flow of cocaine into the United States from South America have made drug trafficking operations more widespread and harder to eradicate, according to new research published this week in Proceedings of the National Academy of Sciences. The National Science Foundation supported the study, which included an Oregon State University geographer and was led by Nicholas Magliocca […]

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Exercise helps prevent cartilage damage caused by arthritis

Exercise helps to prevent the degradation of cartilage caused by osteoarthritis, according to a new study from Queen Mary University of London. The researchers show for the first time how mechanical forces experienced by cells in joints during exercise prevent cartilage degradation by suppressing the action of inflammatory molecules which cause osteoarthritis. The study, published in the journal Osteoarthritis and […]

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TB: Promising new drugs for old pathogen Mtb

Tuberculosis (TB), an ancient and notoriously difficult disease to treat, has killed millions through the course of human history; and the antibiotics that have been used to fight the disease in recent history are becoming less and less effective. In the face of this reality, Dennis Wright, professor of medicinal chemistry in the University of Connecticut’s Department of Pharmaceutical Sciences, […]

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Experiments with roundworms suggest alternatives for the treatment of schizophrenia: Researchers used C. elegans as an animal model to investigate the importance of certain human genes for the treatment of schizophrenia.

A group of Brazilian scientists have long conducted experiments with roundworms to investigate the role of schizophrenia-linked genes in patients’ response to antipsychotic drugs. The results obtained thus far point to new ways of understanding resistance to certain classes of medication. The studies are conducted by researchers in the Pharmacology Department of the Federal University of São Paulo’s Medical School […]

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Potential cystic fibrosis treatment uses ‘molecular prosthetic’ for missing lung protein

An approved drug normally used to treat fungal infections could also do the job of a protein channel that is missing in the lungs of people with cystic fibrosis, operating as a prosthesis on the molecular scale, says new research from the University of Illinois and the University of Iowa. Cystic fibrosis is a lifelong disease that makes patients vulnerable […]

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Opioid crisis: Only a US phenomenon? Prescription opioid use rises in the Nordic countries

Addiction to prescription opioids has reached a crisis level in the United States. Now the drug is causing concern across the Atlantic. Researchers from Denmark, Norway and Sweden urge caution after discovering that prescriptions for the pain medication oxycodone have significantly increased during the last decade. The opioid crisis in the United States shows no sign of abating. On average, […]

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Growing evidence: Water as a potential treatment for inherited cause of kidney failure

People with polycystic kidney disease (PKD) could benefit from a moderate increase in water intake, according to new research. A study from The Westmead Institute for Medical Research found that a moderate increase in water intake in rats with PKD led to a long-term reduction in kidney cyst growth and fibrosis. This latest findings add to the growing body of […]

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Study reveals that night and weekend births have substantially higher risk of delivery complications

As if expecting mothers didn’t have enough to worry about, a new study published in Risk Analysis: An International Journal found that the quantity of delivery complications in hospitals are substantially higher during nights, weekends and holidays, and in teaching hospitals. Each year, nearly four million women give birth in U.S. hospitals, making childbirth the most common cause of hospitalization […]

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