New yardstick offers diagnostic and treatment guidance for idiopathic anaphylaxis: Guidelines on next steps when there is no clear cause of severe reactions

Many people in danger of the severe allergic reaction known as anaphylaxis understand exactly what they need to avoid to stay safe. For some it’s an allergy to food, for others it can be insect stings, medications, hormones or even physical factors like exercise. But according to the new “Idiopathic Anaphylaxis Yardstick,” there are people for whom diagnosis and treatment […]

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Promising treatment for an incurable, deadly kidney disease

A potential treatment for polycystic kidney disease — a genetic disorder that causes the kidneys to swell with multiple cysts and can eventually lead to organ failure — has shown promising results in animal testing. A study describing the drug’s development and testing appears today in Nature Communications. The study shows an approximately 50 percent reduction in kidney size in […]

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Popular pain medication associated with greater risk of hypoglycemia: Tramadol, an opioid, is widely used to treat moderate or severe pain, but patients may be at risk of low blood sugar levels

Since its approval in 1995, the opioid tramadol (marketed as ConZip and Ultram) has become a widely prescribed remedy for osteoarthritis and other painful indications, in part because it presents a lesser risk for some side effects and has a lower abuse potential when compared to other opioids. It is currently ranked among the top five prescribed opioids and top […]

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Charcoal-based drug delivery system improves efficacy of common herpes drug

A study led by researchers from the University of Illinois at Chicago has found that combining acyclovir — a commonly prescribed topical herpes medication — with particles of activated carbon improves efficacy of the drug. This new approach allows for less frequent dosing and overall course of treatment while providing some protection from infection by the virus as well, opening […]

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Newly developed approach shows promise in silencing HIV infection

Researchers from The University of Texas Medical Branch at Galveston have discovered a new potential medication that works with an HIV-infected person’s own body to further suppress the ever present but silent virus that available HIV treatments are unable to combat. Although the potential new drug could complement the current HIV anti-retroviral therapy (ART) medications, it may also be possible […]

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New compounds could be used to treat autoimmune disorders

The immune system is programmed to rid the body of biological bad guys — like viruses and dangerous bacteria — but its precision isn’t guaranteed. In the tens of millions of Americans suffering from autoimmune diseases, the system mistakes normal cells for malicious invaders, prompting the body to engage in self-destructive behavior. This diverse class of conditions, which includes Type […]

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Ragweed compounds could protect nerve cells from Alzheimer’s

As spring arrives in the northern hemisphere, many people are cursing ragweed, a primary culprit in seasonal allergies. But scientists might have discovered a promising new use for some substances produced by the pesky weed. In ACS’ Journal of Natural Products, researchers have identified and characterized ragweed compounds that could help nerve cells survive in the presence of Alzheimer’s disease […]

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A deep-dive into the impact of arthritis drugs on gene expression: New analytical approach could serve as powerful tool to evaluate and compare treatments

A new computational framework has revealed key differences between four rheumatoid arthritis medications and their impact on biological pathways in mice. Niki Karagianni of Biomedcode Hellas SA, Greece, and colleagues present their new approach and findings in PLOS Computational Biology. People with rheumatoid arthritis often receive medications that target and inhibit Tumor-Necrosis Factor (TNF), a protein involved in the painful […]

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‘NarcoLogic’ computer model shows unintended consequences of cocaine interdiction

Efforts to curtail the flow of cocaine into the United States from South America have made drug trafficking operations more widespread and harder to eradicate, according to new research published this week in Proceedings of the National Academy of Sciences. The National Science Foundation supported the study, which included an Oregon State University geographer and was led by Nicholas Magliocca […]

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Exercise helps prevent cartilage damage caused by arthritis

Exercise helps to prevent the degradation of cartilage caused by osteoarthritis, according to a new study from Queen Mary University of London. The researchers show for the first time how mechanical forces experienced by cells in joints during exercise prevent cartilage degradation by suppressing the action of inflammatory molecules which cause osteoarthritis. The study, published in the journal Osteoarthritis and […]

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