New yardstick offers diagnostic and treatment guidance for idiopathic anaphylaxis: Guidelines on next steps when there is no clear cause of severe reactions

Many people in danger of the severe allergic reaction known as anaphylaxis understand exactly what they need to avoid to stay safe. For some it’s an allergy to food, for others it can be insect stings, medications, hormones or even physical factors like exercise. But according to the new “Idiopathic Anaphylaxis Yardstick,” there are people for whom diagnosis and treatment […]

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Promising treatment for an incurable, deadly kidney disease

A potential treatment for polycystic kidney disease — a genetic disorder that causes the kidneys to swell with multiple cysts and can eventually lead to organ failure — has shown promising results in animal testing. A study describing the drug’s development and testing appears today in Nature Communications. The study shows an approximately 50 percent reduction in kidney size in […]

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Genetic discovery linked to rare eye disease

John A. Moran Eye Center physician-researcher Paul S. Bernstein, MD, PhD, and his patients at the University of Utah played a key role in the recent discovery of the first genetic cause for a rare eye disease. Macular telangiectasia type 2 (MacTel) affects about one in 5,000 people, causing a gradual loss of central vision, typically after age 40. As […]

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Survey shows many primary care doctors are unprepared to help patients avoid diabetes

Which of these is not a risk factor for prediabetes? A) Overweight B) Age 45 or older C) Being white D) Exercise less than three times per week The correct response is C — the actual risk factor being African American, Latino, Native American or Asian American. If you didn’t get it right, don’t feel badly. Chances are your doctor […]

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Popular pain medication associated with greater risk of hypoglycemia: Tramadol, an opioid, is widely used to treat moderate or severe pain, but patients may be at risk of low blood sugar levels

Since its approval in 1995, the opioid tramadol (marketed as ConZip and Ultram) has become a widely prescribed remedy for osteoarthritis and other painful indications, in part because it presents a lesser risk for some side effects and has a lower abuse potential when compared to other opioids. It is currently ranked among the top five prescribed opioids and top […]

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New tool mines scientific texts for fusion protein facts: Computational approach could aid efforts to develop personalized cancer treatments

A new computational tool called ProtFus screens scientific literature to validate predictions about the activity of fusion proteins — proteins encoded by the joining of two genes that previously encoded two separate proteins. Somnath Tagore in the Frenkel-Morgenstern Lab at Bar-Ilan University, Israel, and colleagues present ProtFus in PLOS Computational Biology. Different kinds of fusion proteins can arise naturally in […]

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What drives inflammation in type 2 diabetes? Not glucose, says new research

To date, the underlying causes of inflammation in obesity and type 2 diabetes mellitus (T2DM) have been poorly understood, which has hampered efforts to develop treatments to prevent complications from a disease that is the third leading cause of death in the United States. But new research at the University of Kentucky shows that changes to mitochondria — the powerhouse […]

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Athletes at a higher risk for ACL injury after return to sport

Young athletes who do not achieve a 90 percent score on a battery of tests that measure fitness to return to athletic competition, including quadricep strength, are at increased risk for a second knee injury, according to research presented at the Annual Meeting of the American Orthopedic Society of Sports Medicine. Orthopedic surgeons and sports medicine professionals have established return-to-sports […]

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New gene linked to healthy aging in worms

People with the same lifespan do not necessarily have the same quality of life. As we live longer, extending quality of life — “healthspan” — is gaining importance. Scientists at the Okinawa Institute of Science and Technology Graduate University (OIST) have discovered a gene linked with healthy ageing in the roundworm C. elegans, shedding light on the genetics of healthspan. […]

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Superbug virulence regulatory mechanism revealed: Pave ways for developing new antibiotics

As antibiotic resistance is growing and posing a threat on public health, developing new antibiotics has become more urgent than ever. Researchers at City University of Hong Kong (CityU) have recently revealed the virulence regulatory mechanism in Pseudomonas aeruginosa, a superbug which is common in patients with a weak immune system and is resistant to many antibiotics. The findings pave […]

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