Potential cystic fibrosis treatment uses ‘molecular prosthetic’ for missing lung protein

An approved drug normally used to treat fungal infections could also do the job of a protein channel that is missing in the lungs of people with cystic fibrosis, operating as a prosthesis on the molecular scale, says new research from the University of Illinois and the University of Iowa. Cystic fibrosis is a lifelong disease that makes patients vulnerable […]

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Therapy could improve and prolong sight in those suffering vision loss: Damping noise in hyperactive eye cells allows details to emerge

Millions of Americans are progressively losing their sight as cells in their eyes deteriorate, but a new therapy developed by researchers at the University of California, Berkeley, could help prolong useful vision and delay total blindness. The treatment — involving either a drug or gene therapy — works by reducing the noise generated by nerve cells in the eye, which […]

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Deep brain stimulation sites for OCD target distinct symptoms: Two DBS sites equally reduced OCD symptoms but improved distinct symptoms

Deep brain stimulation (DBS) reduces symptoms of severe obsessive-compulsive disorder (OCD) during stimulation of either the ventral capsule (VC) or anteromedial subthalamic nucleus (amSTN), according to a study in Biological Psychiatry. DBS of the regions reduced OCD symptoms to a similar extent, but produced distinct effects on specific symptoms — VC stimulation drastically improved mood, whereas amSTN stimulation in the […]

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Happy in marriage? Genetics may play a role

People fall in love for many reasons — similar interests, physical attraction, and shared values among them. But if they marry and stay together, their long-term happiness may depend on their individual genes or those of their spouse, says a new study led by Yale School of Public Health researchers. Published in the journal PLOS ONE, the study examined the […]

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Cancer genes’ age and function strongly influence their mutational status

Researchers have provided new insight on why some genes that formed during the evolution of the earliest animals on earth are particularly impaired (or dysregulated) by specific mechanisms during cancer development. Their study, published today in eLife, suggests investigating the implications of this dysregulation for the entire function of cancer cells may provide useful insights for the development of potential […]

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Genetic study of impulsiveness reveals associations with psychiatric disorders

Impulsiveness and substance use share a genetic basis, according to genome-wide association studies published in JNeurosci by academic and industry researchers. With more than 20,000 participants, the research represents the largest genetic analysis of impulsive personality traits to date. Dr. Abraham Palmer and colleagues compared genetic data with self-reported impulsive personality traits and history of drug experimentation from a large […]

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Personalized treatment benefits kidney cancer patients

 Personalized treatment plans may extend life expectancy for early-stage kidney cancer patients who have risk factors for worsening kidney disease, according to a new study published in the journal Radiology. Kidney, or renal, tumors are often discovered at an early stage and are frequently treated with partial nephrectomy, a surgical procedure in which the tumor and part of the kidney […]

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After naloxone, when can opioid overdose patients be safely discharged? Study confirms one hour rule

  Naloxone has saved thousands of lives. But can patients be safely discharged from the Emergency Department (ED) just an hour after they receive the medication that curtails drug overdoses? According to the St. Paul’s Early Discharge Rule developed in 2000, that’s how long providers should observe patients after naloxone treatment, so long as their vital signs meet specific criteria […]

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Millions of low-risk people with diabetes may be testing their blood sugar too often

For people with Type 2 diabetes, the task of testing their blood sugar with a fingertip prick and a drop of blood on a special strip of paper becomes part of everyday life. But a new study suggests that some of them test more often than they need to. In fact, the research shows, 14 percent of people with Type […]

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Early clinical trial data show gene therapy reversing sickle cell anemia: Treatment uses reduced-intensity preconditioning to enhance its global transportability

After over a decade of preclinical research and development, a new gene therapy treatment for sickle cell anemia (SCA) is reversing disease symptoms in two adults and showing early potential for transportability to resource-challenged parts of the world where SCA is most common. Preliminary data from a pilot Phase 1-2 clinical trial testing the gene-addition therapy were presented Dec. 3 […]

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