Smart brain stimulators: Next-gen Parkinson’s disease therapy

Researchers at the University of Houston have found neuro biomarkers for Parkinson’s disease that can help create the next generation of “smart” deep brain stimulators, able to respond to specific needs of Parkinson’s disease patients. Those with the disease often undergo the high-frequency brain stimulation, a well-established therapy for the progressive nervous system disorder that affects movement, but the therapy […]

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Defects in heart valve cilia during fetal development cause mitral valve prolapse

Genetic variation in heart valve cells of the developing fetus create the blueprint for the later development of mitral valve prolapse, according to the cover story of today’s Science Translational Medicine. The mutations cause defects in antenna-like cellular structures called primary cilia that previously had no known function in the heart valves. These findings were made possible by an international […]

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Automatic neurological disease diagnosis using deep learning: Analyzing brain waveforms using neuroimaging big data helps improve diagnosis accuracy

A team of researchers from Osaka University and The University of Tokyo developed MNet, an automatic diagnosis system for neurological diseases using magnetoencephalography (MEG) , demonstrating the possibility of making automatic neurological disease diagnoses using MEG. Their research results were published in Scientific Reports. MEG and electroencephalography (EEG) are essential for diagnosing neurological diseases such as epilepsy. MEG allows for […]

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New computational tool improves gene identification

Like finding a needle in a haystack, identifying genes that are involved in particular diseases can be an arduous and time consuming process. Looking to improve this process, a team led by researchers at Baylor College of Medicine has developed a new bioinformatics tool that analyzes CRISPR pooled screen data and identifies candidates for potentially relevant genes with greater sensitivity […]

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Ketamine reverses neural changes underlying depression-related behaviors in mice: Study sheds light on the neural mechanisms underlying remission of depression

Researchers have identified ketamine-induced brain-related changes that are responsible for maintaining the remission of behaviors related to depression in mice — findings that may help researchers develop interventions that promote lasting remission of depression in humans. The study, funded by the National Institute of Mental Health (NIMH), part of the National Institutes of Health, appears in the journal Science. Major […]

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Parkinson’s clues seen in tiny fish could aid quest for treatments

Parkinson’s patients could be helped by fresh insights gained from studies of tiny tropical fish. Research using zebrafish has revealed how key brain cells that are damaged in people with Parkinson’s disease can be regenerated. The findings offer clues that could one day lead to treatments for the neurological condition, which causes movement problems and tremors. Parkinson’s occurs when specialised […]

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Diagnosing and treating personality disorders needs a dynamic approach

Someone who is “neurotic” does not necessarily show anger or anxiety in a given situation, even though those are generally accepted traits of a person with that personality style. New University of California, Davis, research suggests that lumping those with personality disorders into a package of traits should be left behind for more dynamic analysis instead. Those who study and […]

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