New blood test uses DNA ‘packaging’ patterns to detect multiple cancer types

Researchers at the Johns Hopkins Kimmel Cancer Center have developed a simple new blood test that can detect the presence of seven different types of cancer by spotting unique patterns in the fragmentation of DNA shed from cancer cells and circulating in the bloodstream. In a proof-of-concept study, the test, called DELFI (DNA evaluation of fragments for early interception), accurately […]

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Conquering cancer’s infamous KRAS mutation

KRAS is one of the most challenging targets in cancer. Despite its discovery more than 60 years, researchers still struggle to inhibit its mutated form — earning its reputation as “undruggable.” Yet, the hunt for an Achilles’ heel continues, as cancers driven by KRAS mutations are both common and deadly. Now, scientists from Sanford Burnham Prebys and PHusis Therapeutics have […]

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Removal of gene completely prevents development of aggressive pancreatic cancer in mice

The action of a gene called ATDC is required for the development of pancreatic cancer, a new study finds. The work builds on the theory that many cancers arise when adult cells — to resupply cells lost to injury and inflammation — switch back into more “primitive,” high-growth cell types, like those that drive fetal development. When this reversion happens […]

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Cancers ‘change spots’ to avoid immunotherapy

Cancers can make themselves harder for new immunotherapies to see by ‘changing their spots’ — and switching off a key molecule on the surface of cells that is otherwise recognised by treatment. Researchers found that they could test samples from patients with bowel cancer to identify which were most likely to respond to immunotherapy by assessing molecular changes within miniature […]

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Blocking epigenetic Swiss army knife may be a new strategy for treating colorectal cancer

A new study out today in Cancer Cell shows that blocking specific regions of a protein called UHRF1 switches on hundreds of cancer-fighting genes, impairing colorectal cancer cells’ ability to grow and spread throughout the body. “Colorectal cancers are a growing public health problem, particularly in young people who haven’t yet reached the recommended age for regular screening,” said Scott […]

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Small risks may have big impact on breast cancer odds of childhood cancer survivors

St. Jude Children’s Research Hospital researchers have evidence that common genetic variations can help to identify pediatric cancer survivors who are at increased risk for developing breast cancer while relatively young. The findings appear today in the journal Clinical Cancer Research. The research focused on the combined effect of 170 common genetic variations that individually confer a modest increased risk […]

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