New microscopes unravel the mysteries of brain organization: Researchers around the world share their stunning images and insights: The open source mesoSPIM Initiative

The secret of capturing exquisite brain images with a new generation of custom-built microscopes is revealed today in Nature Methods. The new microscopes, known as mesoSPIMs, can image the minute detail of brain tissue down to individual neurons that are five times thinner than a human hair, and can uncover the 3D anatomy of entire small organs, faster than ever […]

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Mystery solved about the machines that move your genes

Fleets of microscopic machines toil away in your cells, carrying out critical biological tasks and keeping you alive. By combining theory and experiment, researchers have discovered the surprising way one of these machines, called the spindle, avoids slowdowns: congestion. The spindle divides chromosomes in half during cell division, ensuring that both offspring cells contain a full set of genetic material. […]

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Gold nanoparticles shown to be safe and effective treatment for prostate cancer

Biocompatible gold nanoparticles designed to convert near-infrared light to heat have been shown to safely and effectively ablate low- to intermediate-grade tumors within the prostate, according to a study conducted at the Icahn School of Medicine and published in the journal Proceedings of the National Academy of Sciences. This treatment could offer patients a targeted therapy option that would preserve […]

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Augmented reality glasses may help people with low vision better navigate their environment: Glasses enhance mobility and function in patients who have difficulty with peripheral vision or seeing in low light

Nearly one in 30 Americans over the age of 40 experience low vision — significant visual impairment that can’t be corrected with glasses, contact lenses, medication or surgery. In a new study of patients with retinitis pigmentosa, an inherited degenerative eye disease that results in poor vision, Keck School of Medicine of USC researchers found that adapted augmented reality (AR) […]

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Tiny lensless endoscope captures 3D images of objects smaller than a cell: Self-calibrating technology opens new opportunities for medicine and research

Researchers have developed a new self-calibrating endoscope that produces 3D images of objects smaller than a single cell. Without a lens or any optical, electrical or mechanical components, the tip of the endoscope measures just 200 microns across, about the width of a few human hairs twisted together. As a minimally invasive tool for imaging features inside living tissues, the […]

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Ultrasound-assisted optical imaging to replace endoscopy in breakthrough discovery

Carnegie Mellon University’s Assistant Professor of Electrical and Computer Engineering (ECE) Maysam Chamanzar and ECE Ph.D. student Matteo Giuseppe Scopelliti today published research that introduces a novel technique which uses ultrasound to noninvasively take optical images through a turbid medium such as biological tissue to image body’s organs. This new method has the potential to eliminate the need for invasive […]

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New 3D microscope visualizes fast biological processes better than ever

“Many important biological processes occur in three dimensions and on millisecond timescales,” says Lars Hufnagel on the rationale for developing the new microscope. Capturing these fast processes is a big challenge in biology. And showing them not only in 2D but in 3D is — next to the needed high resolution — the second main aspect of modern microscopy. The […]

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Detecting pollution with a compact laser source

Researchers at EPFL have come up with a new middle infrared light source that can detect greenhouse and other gases, as well as molecules in a person’s breath. The compact system, which resembles a tiny suitcase, contains just two parts: a standard laser together with a photonic chip measuring a few millimeters across. The research is detailed in an article […]

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New microscope captures large groups of neurons in living animals: Fast, detailed imaging across a wide field of view useful for deciphering brain functions

Researchers have developed a microscope specifically for imaging large groups of interacting cells in their natural environments. The instrument provides scientists with a new tool for imaging neurons in living animals and could provide an unprecedented view into how large networks of neurons interact during various behaviors. In Optica, The Optical Society’s journal for high-impact research, researchers from Boston University, […]

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Diattenuation imaging: Promising imaging technique for brain research

A new imaging method provides structural information about brain tissue that was previously difficult to access. Diattenuation Imaging (DI), developed by scientists at Forschungszentrum Jülich and the University of Groningen, allows researchers to differentiate, e.g., regions with many thin nerve fibres from regions with few thick nerve fibres. With current imaging methods, these tissue types cannot easily be distinguished. The […]

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