New method described for quantifying antisense oligonucleotides in nuclei

A novel method uses subcellular fractionation to quantify label-free antisense oligonucleotides (AONs)- designed to silence targeted genes—that have crossed into the nucleus of a cell, where they can exert their effects. Researchers used this method to correlate nuclear entry of several AON molecules with target gene knockdown and they report their results in Nucleic Acid Therapeutics. Troels Koch and colleagues […]

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New York raises age to purchase tobacco and e-cigarette products to 21

New York state records its first vaping-illness death A 17-year-old boy has been confirmed as New York’s first death connected to vaping. The teen died Oct 4. at The Children’s Hospital at the Montefiore Medical Center in Bronx, NY. New Yorkers hoping to purchase tobacco or e-cigarette products in the state must be 21 years of age to do so, […]

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New strategy for encapsulating nutrients makes it easier to fortify foods with iron and vitamin A

About 2 billion people around the world suffer from deficiencies of key micronutrients such as iron and vitamin A. Two million children die from these deficiencies every year, and people who don’t get enough of these nutrients can develop blindness, anemia, and cognitive impairments. MIT researchers have now developed a new way to fortify staple foods with these micronutrients by […]

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Study finds new option for liver transplant patients

A drug commonly used to treat both asthma and inflammatory bowel disease, budesonide, may also be useful as an anti-organ rejection medication for liver transplant patients leading to fewer serious side effects than the most commonly used therapy, according to a University of Cincinnati researcher. Dr. Khurram Bari, an associate professor in the UC Division of Digestive Diseases, explains the […]

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Researchers report new insights into Parkinson’s disease-related mortality

By following a group of newly diagnosed patients with Parkinson’s disease (PD) for a decade or more, researchers have been able to identify several factors never before reported that appear to be associated with higher mortality rates in PD patients compared to the general population. As reported in the Journal of Parkinson’s Disease, these factors are early onset of PD, […]

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Initial reports suggest new dengue vaccine safer than prior vaccines

A team of researchers at Takeda Vaccines has announced the results of the first phase of trial testing a new vaccine to prevent dengue infections. In their paper published in The New England Journal of Medicine, they outline their trial and how well the drug is working in test cases. The dengue virus infects hundreds of millions of people every […]

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New technique lays foundation for regenerative cardiac therapies

Scientists have devised a technique to sort out which heart cells can replicate and which cannot, a critical step toward treatments that may one day help the heart heal itself after injury. The method, published in the journal Circulation Research, removes a significant roadblock to developing ways to regrow healthy cardiac muscle tissue, a feat not currently possible. “This new […]

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Scientists discover a new strain of HIV for the first time since 2000

Scientists find new strain of HIV for the first time since 2000 – and they say the discovery is a step toward ending the pandemic by including it in testing, treatment and potential vaccines Scientists at Abbott Labs have confirmed that a strain of HIV that infected three people in the Democratic Republic of Congo is a new variety of […]

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New clues found to help protect heart from damage after heart attack

Studying mice, scientists have shown that boosting the activity of specific immune cells in the heart after a heart attack can protect against developing heart failure, an invariably fatal condition. Patients with heart failure tire easily and become breathless from everyday activities because the heart muscle has lost the ability to pump enough blood to the body. The study, by […]

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New research suggests proton radiation can benefit pts with challenging liver tumors

Two new studies support and inform the use of proton radiation therapy to treat patients with hepatocellular carcinoma (HCC), a common but often fatal type of liver cancer for which there are limited treatment options. One study (Sanford et al.) suggests that proton radiation, compared to traditional photon radiation, can extend overall survival with reduced toxicity. A second study (Hsieh […]

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