A new genetic tool to modify and understand gene function

Scientists of the National Center for Cardiovascular Research (CNIC) led by Rui Benedito have developed a new genetic tool called iSuRe-Cre that provides certainty in Cre-inducible genetic modifications, a key technique for understanding gene function. Most analysis of gene function in biomedical research relies on the use of Cre-lox technology. Since its introduction in 1994, this technology has revolutionized biomedical […]

Read more

Children with cancer wait an average of 6.5 years longer than adults to access new drugs

Cancer drugs approved by the U.S. Food and Drug Administration (FDA) took a median of 6.5 years to go from the first clinical trial in adults to the first trial in children, according to a study at the Dana-Farber/Boston Children’s Cancer and Blood Disorders Center. The study was published in the May issue of the European Journal of Cancer. “Despite […]

Read more

A new approach to targeting cancer cells

A University of California, Riverside, research team has come up with a new approach to targeting cancer cells that circumvents a challenge faced by currently available cancer drugs. A cancer target is often a rogue protein that signals cancer cells to proliferate uncontrollably and invade organs. Modern cancer drugs have emerged that work by striking a tight bond between the […]

Read more

A new approach to targeting tumors and tracking their spread

The spread of malignant cells from an original tumor to other parts of the body, known as metastasis, is the main cause of cancer deaths worldwide. Early detection of tumors and metastases could significantly improve cancer survival rates. However, predicting exactly when cancer cells will break away from the original tumor, and where in the body they will form new […]

Read more

New research reviews the state of vaccine safety science

A new systematic review provides a succinct summary of the scientific evidence for and/or against causal associations for 47 adverse events following immunization (AEFI). Findings from the study will be presented during the Pediatric Academic Societies (PAS) 2019 Meeting, taking place on April 24—May 1 in Baltimore. “Health care providers desire objective and clear information on a broad range of […]

Read more

Blood cancer’s Achilles’ heel opens door for new treatments

New findings about a fatal form of blood cancer could aid the development of new drugs with significantly less harmful side effects than existing chemotherapy. The discovery could lead to novel treatments that efficiently eliminate blood cancer cells in acute myeloid leukaemia (AML), without harming healthy blood cells. Researchers have discovered how a protein in the body plays a key […]

Read more

Analyzing colon cancer proteins and genes uncovers new potential treatments

Analyzing both the entire set of genes and all the proteins produced by colon cancer tissues from patient samples has revealed a more comprehensive view of the tumor that points at novel cancer biological mechanisms and possible new therapeutic strategies. This multidisciplinary and multi-institutional study led by researchers at Baylor College of Medicine and published in the journal Cell, strongly […]

Read more

New discovery in how mammals sense the cold could lead to new pain relief drugs

Researchers at UCL have shown for the first time that mammals detect different intensities of cold using distinct sensory neuron systems, a finding which could lead to the development of new drugs to treat cold pain. The study on mice, published in Proceedings of the National Academy of Sciences, set out to understand more about the two known sensory neuron […]

Read more

New CRISPR tool executes multiple edits simultaneously, leading to unique partnership to deliver cancer treatments

Scientists at Christiana Care Health System’s Gene Editing Institute and NovellusDx, an Israeli biotechnology company, have deployed a breakthrough CRISPR gene-editing tool to successfully engineer multiple edits simultaneously to fragments of DNA extracted from a human cell, according to a new study published today in The CRISPR Journal. The tool can rapidly reproduce, in a human DNA sample, the unique […]

Read more

New drug mimics benefits of ketamine for depression

A new small-molecule drug produced a rapid antidepressant response similar to that of ketamine when tested in mice, a new Yale-led study published April 16 in the Journal of Clinical Investigation shows. The effects of the drug, called NV-5138, in rodent models mimicked the rapid actions of the anesthetic ketamine, a variation of which, Esketamine, was recently approved by the […]

Read more
1 2 3 7