New method described for quantifying antisense oligonucleotides in nuclei

A novel method uses subcellular fractionation to quantify label-free antisense oligonucleotides (AONs)- designed to silence targeted genes—that have crossed into the nucleus of a cell, where they can exert their effects. Researchers used this method to correlate nuclear entry of several AON molecules with target gene knockdown and they report their results in Nucleic Acid Therapeutics. Troels Koch and colleagues […]

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Researchers develop noninvasive method to detect early-stage liver disease

A safer and more sensitive contrast dye for MRI tests developed by a team led by Georgia State University researchers may provide the first effective, noninvasive method for detecting and diagnosing early-stage liver diseases, including liver fibrosis. “It’s a revolutionary change for the field as the first robust detection of the early stage of liver fibrosis,” said Jenny Yang, a […]

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New diagnostic method for fungal infections could combat a major global health risk

A new study from The Westmead Institute for Medical Research (WIMR) has demonstrated how dual DNA barcoding could help improve the diagnosis of invasive fungal diseases, giving patients access to potentially life-saving treatment much sooner. The early detection of fungal pathogens—the specific species of fungi responsible for disease—is crucial in ensuring that patients have fast access to treatment, preventing complications. […]

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Became known new way to destroy cancer

Scientists at the University of Otago (New Zealand) learned how the virus Seneca valley infects cancer cells and kills them. In the future this will create a new method of treatment of malignant tumors. About it reported in a press release on EurekAlert!. Experts have observed for infection of tumor cells by the virus via cryoelectronic of high-resolution microscopy in […]

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