Metformin may help patients maintain weight loss long-term

In the Diabetes Prevention Program (DPP) clinical trial and its long-term follow-up study, among the persons who lost at least 5 percent of their body weight during the first year, long-term maintenance of weight loss was more likely if they had been assigned to treatment with metformin than with placebo or lifestyle intervention. Being older and losing a greater amount […]

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For busy medical students, two-hour meditation study may be as beneficial as longer course

For time-crunched medical students, taking a two-hour introductory class on mindfulness may be just as beneficial for reducing stress and depression as taking an eight-week meditation course, a Rutgers study finds. The study, conducted by researchers at Rutgers Robert Wood Johnson Medical School, is published in the journal Medical Science Educator. The researchers say many medical students would like to […]

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Researcher reports skin properties that may limit cancer and aid stem cell regeneration

Two images published in a Cell Stem Cell paper in September 2018 summarize years of relentless questioning on how skin stem cells regenerate, which has driven much of the research of Valentina Greco, Ph.D., Carolyn Walch Slayman Professor of Genetics and professor of cell biology and of dermatology, and her lab members. The side-by-side images feature individual mouse cells in […]

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How education may stave off cognitive decline

Prefrontal brain regions linked to higher educational attainment are characterized by increased expression of genes involved in neurotransmission and immunity, finds a study of healthy older adults published in JNeurosci. The identified genes and molecular pathways could provide insight into factors that help keep the brain sharp in old age. In their study of 122 Spanish adults, David Bartrés-Faz (University […]

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Computational model of a human kinase may provide insights for cancer treatment

Researchers have developed a computational model for human MEK1, a protein with potential as a drug target for a variety of human cancers. The initiation and progression of cancer cells occur when molecular signals involved in cellular proliferation go awry. MEK1 plays an essential role in signaling within both healthy and cancer cells. While much is known about the key […]

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Ocular protein levels may be useful for Alzheimer testing

(HealthDay)—Patients with poor cognitive function have significantly lower levels of Alzheimer disease-related biomarkers in the vitreous humor, according to a study published March 8 in the Journal of Alzheimer’s Disease. Lauren M. Wright, M.D., from the Boston University School of Medicine, and colleagues analyzed vitreous humor samples from 80 eyes of 80 individuals to quantify levels of beta amyloid-β (Aβ40, […]

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Study may explain why immunotherapy not effective for some patients with metastatic melanoma and kidney cancer

White blood cells known as B cells have been shown to be effective for predicting which cancer patients will respond to immune checkpoint blockade (ICB) therapy, according to a study at The University of Texas MD Anderson Cancer Center. Study results will be presented April 2 at the AACR Annual Meeting 2019 in Atlanta. The study, led by Jennifer Wargo, […]

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Delusions may stem from sticky beliefs, study finds

Delusions are one of the most common symptoms of psychosis, but little is known about what causes them. A new study from researchers at Columbia University and New York State Psychiatric Institute offers insight into the development of delusions, which could lead to better treatments for people with psychosis. The findings were published in Brain. An estimated 80-90 percent of […]

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Hookah smokers are inhaling toxic chemicals that may harm the heart

Smoking tobacco in waterpipes, more commonly known as hookahs, results in inhaling toxic chemicals, often at levels exceeding cigarette smoke, that may harm the heart and blood vessels, according to a new scientific statement published in the American Heart Association’s journal Circulation. Waterpipes go by many names—hookah, narghile, argileh, shisha and goza—and usually consist of a head or bowl that […]

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Electronic order set may reduce inappropriate ECG monitoring

(HealthDay)—Use of electronic order sets is a safe and effective way to enhance appropriate electrocardiographic (ECG) monitoring of hospitalized patients, according to a study published in the March issue of the American Journal of Critical Care. Sue Sendelbach, Ph.D., retired from the Abbott Northwestern Hospital/Minneapolis Heart Institute/Allina Health in Minnesota, and colleagues evaluated the impact of implementing an electronic order […]

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