Biologists design new molecules to help stall lung cancer: Scientists tie tumor growth to heme availability, build peptide to ‘hijack’ uptake

University of Texas at Dallas scientists have demonstrated that the growth rate of the majority of lung cancer cells relates directly to the availability of a crucial oxygen-metabolizing molecule. In a preclinical study, recently published in Cancer Research, biologist Dr. Li Zhang and her team showed that the expansion of lung tumors in mice slowed when access to heme — […]

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Cell-killing proteins suppress listeria without killing cells

New North Carolina State University research shows that key proteins known for their ability to prevent viral infections by inducing cell death can also block certain bacterial infections without triggering the death of the host cells. Rather than killing host cells infected by Listeria in the gastrointestinal tract, the RIPK3 and MLKL proteins recognize the chemical composition of the bacteria […]

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Cancers ‘change spots’ to avoid immunotherapy

Cancers can make themselves harder for new immunotherapies to see by ‘changing their spots’ — and switching off a key molecule on the surface of cells that is otherwise recognised by treatment. Researchers found that they could test samples from patients with bowel cancer to identify which were most likely to respond to immunotherapy by assessing molecular changes within miniature […]

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Copycat fungus deceives immune system and deactivates body’s response to infection

Fungus can imitate signals from our immune system and prevent our body from responding to infection, new research from the University of Sheffield has found. Life-threatening fungal infection is a major killer of people with immune system problems such as blood cancers, HIV infection or following organ transplant. The new study focused on one of the most dangerous infections for […]

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How a fungus can cripple the immune system: Research team clarifies the mechanism of gliotoxin, a mycotoxin from the fungus Aspergillus fumigatus

It is everywhere — and it is extremely dangerous for people with a weakened immune system. The fungus Aspergillus fumigatus occurs virtually everywhere on Earth, as a dark grey, wrinkled cushion on damp walls or in microscopically small spores that blow through the air and cling to wallpaper, mattresses and floors. Healthy people usually have no problem if spores find […]

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Malignant bone marrow disease: New hope for MPN patients: Myeloproliferative neoplasms (MPNs) — a group of rare but malignant bone marrow disorders

MPNs are a group of rare, malignant diseases of the bone marrow involving the production of an excess of red blood cells, white blood cells and/or platelets. MPNs are chronic diseases with only 1 to 2 new cases diagnosed per 100,000 people every year. MPNs can affect people at any age, but they are most common among adults around 60 […]

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New hope for stem cell approach to treating diabetes: Insulin-producing cells more responsive to fluctuating glucose levels

Scientists working to develop more effective treatments for diabetes are turning to stem cells. Such cells can be transformed into cells that produce insulin, the hormone that controls blood sugar. But there’s a major challenge: the amount of insulin produced by theses cells is difficult to control. Now, by tweaking the recipe for coaxing human stem cells into insulin-secreting beta […]

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Scientists create a renewable source of cancer-fighting T cells

A study by UCLA researchers is the first to demonstrate a technique for coaxing pluripotent stem cells — which can give rise to every cell type in the body and which can be grown indefinitely in the lab — into becoming mature T cells capable of killing tumor cells. The technique uses structures called artificial thymic organoids, which work by […]

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Mechanism for leukaemia cell growth revealed, prompting new treatment hopes: Research reveals new blood cell mechanism which drives leukaemia growth

A mechanism which drives leukemia cell growth has been discovered by researchers at the University of Sussex, who believe their findings could help to inform new strategies when it comes to treating the cancer. Acute myeloid leukemia (AML) is a devastating blood cancer with around 3,000 new cases annually in the UK. Despite considerable improvement in patient survival over the […]

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How sperm stem cells maintain their number

The steady production of sperm relies on the number of sperm stem cells in the testis remaining constant. Researchers including Asst. Prof. Yu Kitadate and Prof. Shosei Yoshida (developmental biologists at the National Institute for Basic Biology within the National Institutes of Natural Sciences in Japan) and Prof. Benjamin Simons (a theoretical physicist at the University of Cambridge in the […]

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