How a fungus can cripple the immune system: Research team clarifies the mechanism of gliotoxin, a mycotoxin from the fungus Aspergillus fumigatus

It is everywhere — and it is extremely dangerous for people with a weakened immune system. The fungus Aspergillus fumigatus occurs virtually everywhere on Earth, as a dark grey, wrinkled cushion on damp walls or in microscopically small spores that blow through the air and cling to wallpaper, mattresses and floors. Healthy people usually have no problem if spores find […]

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Malignant bone marrow disease: New hope for MPN patients: Myeloproliferative neoplasms (MPNs) — a group of rare but malignant bone marrow disorders

MPNs are a group of rare, malignant diseases of the bone marrow involving the production of an excess of red blood cells, white blood cells and/or platelets. MPNs are chronic diseases with only 1 to 2 new cases diagnosed per 100,000 people every year. MPNs can affect people at any age, but they are most common among adults around 60 […]

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New hope for stem cell approach to treating diabetes: Insulin-producing cells more responsive to fluctuating glucose levels

Scientists working to develop more effective treatments for diabetes are turning to stem cells. Such cells can be transformed into cells that produce insulin, the hormone that controls blood sugar. But there’s a major challenge: the amount of insulin produced by theses cells is difficult to control. Now, by tweaking the recipe for coaxing human stem cells into insulin-secreting beta […]

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Scientists create a renewable source of cancer-fighting T cells

A study by UCLA researchers is the first to demonstrate a technique for coaxing pluripotent stem cells — which can give rise to every cell type in the body and which can be grown indefinitely in the lab — into becoming mature T cells capable of killing tumor cells. The technique uses structures called artificial thymic organoids, which work by […]

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Mechanism for leukaemia cell growth revealed, prompting new treatment hopes: Research reveals new blood cell mechanism which drives leukaemia growth

A mechanism which drives leukemia cell growth has been discovered by researchers at the University of Sussex, who believe their findings could help to inform new strategies when it comes to treating the cancer. Acute myeloid leukemia (AML) is a devastating blood cancer with around 3,000 new cases annually in the UK. Despite considerable improvement in patient survival over the […]

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How sperm stem cells maintain their number

The steady production of sperm relies on the number of sperm stem cells in the testis remaining constant. Researchers including Asst. Prof. Yu Kitadate and Prof. Shosei Yoshida (developmental biologists at the National Institute for Basic Biology within the National Institutes of Natural Sciences in Japan) and Prof. Benjamin Simons (a theoretical physicist at the University of Cambridge in the […]

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A bacterial protein is found to promote cancer: Research suggests suggests that bacterial infections may contribute to far more cancers than previously thought

The Institute of Human Virology (IHV) at the University of Maryland School of Medicine (UMSOM) announced today the discovery that DnaK, a protein of the bacterium mycoplasma, interferes with the mycoplasma-infected cell’s ability to respond to and repair DNA damage, a known origin of cancer. Little or no mycoplasma DnaK DNA sequences were found associated with the tumor, which was […]

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When good macrophages go bad: How cancer manipulates our immune system to become harder to treat

Many factors affect cancer treatment outcome, such as the size and location of the tumor, availability of effective treatments, and timing of intervention. But some cancers are so aggressive that outcome is poor, even after early diagnosis and chemotherapy. Researchers have focused their attention on trying to understand what makes some cancers less treatable than others. Now, researchers at Children’s […]

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FDA Approves First Biosimilar to Non-Hodgkin’s Lymphoma Drug

WEDNESDAY, Nov. 28, 2018 — Truxima (rituximab-abbs) has been approved by the U.S. Food and Drug Administration as the first biosimilar to the non-Hodgkin’s lymphoma drug Rituxan, the agency said today. Truxima, as with Rituxan, is approved to treat adults with CD20-positive, B-cell non-Hodgkin’s lymphoma to be used as a single agent or in combination with chemotherapy. The most common […]

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Mapping of cells in the early human placenta may shed light on problem pregnancies

To treat and prevent pregnancy-related disorders, researchers must understand not only what can go wrong, but when. Complications, such as preeclampsia and pre-term birth, often occur in the second or third trimester, and most research to date has focused on those later stages of pregnancy. But the biological events that lead to these problems could start much earlier. In a […]

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