Patients taking nivolumab experience five-fold increase in overall survival compared to chemotherapy: Five-year outcomes from the randomized, phase 3 trials checkmate 017/057: nivolumab vs. docetaxel in previously treated NSCLC

Pooled data on two clinical trials demonstrate patients taking nivolumab realized a greater than five-fold increase in five-year overall survival rate compared with the chemotherapy docetaxel. The presentation was made today by Dr. Scott Gettinger of Yale Comprehensive Cancer Center, New Haven, Conn., at the IASLC 2019 World Conference on Lung Cancer, hosted by the International Association for the Study […]

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Possible new treatment strategy for lung cancer: Combination therapy targeting KRAS mutation could provide benefit to nearly a third of lung cancer patients

Lung cancer is the second most common cancer found in both men and women. It is estimated there will be roughly 228,000 new lung cancer cases this year, and nearly 30% of those patients will have mutations in the KRAS pathway. This type of mutation makes the cancer more aggressive and difficult to treat. Researchers at Moffitt Cancer Center are […]

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Low level exposure to air pollution is harmful, mouse model shows

Air pollution is made up of both gaseous and particulate matter (PM). Each year almost two million people die as a direct result of air pollution with many more experiencing impaired lung function, developing lung diseases such as asthma and chronic obstructive pulmonary disease (COPD). However research, on the effects of low level air pollution, is often overlooked. An international […]

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Separation anxiety no more: A faster technique to purify elements: A more efficient chemical separation method could accelerate access to promising cancer treatment

The actinides — those chemical elements on the bottom row of the periodic table — are used in applications ranging from medical treatments to space exploration to nuclear energy production. But purifying the target element so it can be used, by separating out contaminants and other elements, can be difficult and time-consuming. Now researchers at the Department of Energy’s Lawrence […]

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New light shed on the harms of air pollution

A new University at Buffalo study based on levels before, during and after the Beijing Olympics reveals how air pollution affects the human body at the level of metabolites. Researchers found that 69 metabolites changed significantly when air pollution changed. Their results were published today (May 29) in the journal Environmental Health Perspectives. The study identified two major metabolic signatures, […]

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Biologists design new molecules to help stall lung cancer: Scientists tie tumor growth to heme availability, build peptide to ‘hijack’ uptake

University of Texas at Dallas scientists have demonstrated that the growth rate of the majority of lung cancer cells relates directly to the availability of a crucial oxygen-metabolizing molecule. In a preclinical study, recently published in Cancer Research, biologist Dr. Li Zhang and her team showed that the expansion of lung tumors in mice slowed when access to heme — […]

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Potential cystic fibrosis treatment uses ‘molecular prosthetic’ for missing lung protein

An approved drug normally used to treat fungal infections could also do the job of a protein channel that is missing in the lungs of people with cystic fibrosis, operating as a prosthesis on the molecular scale, says new research from the University of Illinois and the University of Iowa. Cystic fibrosis is a lifelong disease that makes patients vulnerable […]

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Artificial intelligence cuts lung cancer screening false positives

Lung cancer is the leading cause of cancer deaths worldwide. Screening is key for early detection and increased survival, but the current method has a 96 percent false positive rate. Using machine learning, researchers at the University of Pittsburgh and UPMC Hillman Cancer Center have found a way to substantially reduce false positives without missing a single case of cancer. […]

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Showerhead bacteria and lung infections: Researchers find correlation

Researchers from the University of Colorado, Boulder have now shown that the regions in the United States where pathogenic mycobacteria are most prevalent in showerheads are the same regions where nontuberculous mycobacterial (NTM) lung infections are most common. The study, published in the journal, mBio, emphasizes the important role of showerheads in the transmission of NTM infections. Bacteria thrive in […]

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