Discovery of oral cancer biomarkers could save thousands of lives

Oral cancer is known for its high mortality rate in developing countries, but an international team of scientists hope its latest discovery will change that. Researchers from the University of Otago, New Zealand, and the Indian Statistical Institute (ISI), Kolkata, have discovered epigenetic markers that are distinctly different in oral cancer tissues compared to the adjacent healthy tissues in patients. […]

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Cancers ‘change spots’ to avoid immunotherapy

Cancers can make themselves harder for new immunotherapies to see by ‘changing their spots’ — and switching off a key molecule on the surface of cells that is otherwise recognised by treatment. Researchers found that they could test samples from patients with bowel cancer to identify which were most likely to respond to immunotherapy by assessing molecular changes within miniature […]

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Ovarian cancer patients undertested for mutations that could guide clinical care

Fewer than a quarter of breast cancer patients and a third of ovarian cancer patients diagnosed between 2013 and 2014 in two states underwent genetic testing for cancer-associated mutations, according to a study by researchers at the Stanford University School of Medicine and several other organizations. The findings indicate that substantial gaps exist between national guidelines for testing and actual […]

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Blocking epigenetic Swiss army knife may be a new strategy for treating colorectal cancer

A new study out today in Cancer Cell shows that blocking specific regions of a protein called UHRF1 switches on hundreds of cancer-fighting genes, impairing colorectal cancer cells’ ability to grow and spread throughout the body. “Colorectal cancers are a growing public health problem, particularly in young people who haven’t yet reached the recommended age for regular screening,” said Scott […]

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Study explaining side effects of statins finds drug can have unexpected benefits: Statins can be beneficial during heart attacks and cancer cell metastasis

While investigating why cholesterol-lowering drugs called statins cause negative side effects such as blurred vision, short-term memory loss or increased risk for diabetes, cellular chemists at The University of Toledo discovered several previously unknown benefits. It is well-established statins can help lower the risk of heart attack by lowering blood cholesterol, but statins also may play a protective role in […]

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Potential cystic fibrosis treatment uses ‘molecular prosthetic’ for missing lung protein

An approved drug normally used to treat fungal infections could also do the job of a protein channel that is missing in the lungs of people with cystic fibrosis, operating as a prosthesis on the molecular scale, says new research from the University of Illinois and the University of Iowa. Cystic fibrosis is a lifelong disease that makes patients vulnerable […]

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Artificial intelligence cuts lung cancer screening false positives

Lung cancer is the leading cause of cancer deaths worldwide. Screening is key for early detection and increased survival, but the current method has a 96 percent false positive rate. Using machine learning, researchers at the University of Pittsburgh and UPMC Hillman Cancer Center have found a way to substantially reduce false positives without missing a single case of cancer. […]

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Imaging technique finds differences between radiation-sensitive and resistant tumors: Pilot clinical trials begun

Researchers have started pilot clinical studies in head and neck cancer patients to determine if Raman spectroscopy, a noninvasive imaging technique, can effectively spare some patients of the toxic side effects of ineffective radiation therapy. Researchers at the University of Arkansas, Johns Hopkins University and the University of Arkansas for Medical Sciences (UAMS) used the imaging technique and discovered differences […]

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A new method for developing artificial ovaries

An interdisciplinary team of researchers at Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) led by Prof. Aldo R. Boccaccini from the Chair of Materials Science (biomaterials) and Prof. Dr. Ralf Dittrich from the Department of Obstetrics and Gynaecology at Universitätsklinikum Erlangen have taken an important step towards developing artificial ovaries for patients suffering from cancer. Together, they have been researching innovative techniques for restoring […]

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Cancer patient and research advocate has high hopes for N.B. lung cancer detection prototypes

A Moncton-based company is hoping its breath-sampling, lung cancer-detecting prototype can be ready for use in 2022. Picomole Inc. recently received $818,000 from the federal government to build more of the devices. “The theory is, once we show proof of concept that it’s really the cancer cells putting out the organic compounds, we should be able to see right down […]

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