Kidney disease: Senescent cell burden is reduced in humans by senolytic drugs

In a small safety and feasibility clinical trial, Mayo Clinic researchers have demonstrated for the first time that senescent cells can be removed from the body using drugs termed “senolytics.” The result was verified not only in analysis of blood but also in changes in skin and fat tissue senescent cell abundance. The findings appear in the journal EBioMedicine. This […]

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Screening mammography could benefit men at high risk of breast cancer

Selective mammography screening can provide potentially lifesaving early detection of breast cancer in men who are at high risk for the disease, according to a landmark study published in the journal Radiology. Breast cancer in men is a rare but often deadly disease. The American Cancer Society projects that 2,670 new cases of invasive breast cancer will be diagnosed in […]

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Novel anti-cancer nanomedicine for efficient chemotherapy

Researchers at the University of Helsinki in collaboration with researchers from Åbo Akademi University,Finland and Huazhong University of Science and Technology,China have developed a new anti-cancer nanomedicine for targeted cancer chemotherapy. This new nano-tool provides a new approach to use cell-based nanomedicines for effcient cancer chemotherapy. Exosomes contain various molecular constituents of their cell of origin, including proteins and RNA. […]

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Scientists discover new breakthrough in cancer hair-loss treatment

Scientists have determined a new way to protect the hair follicle from chemotherapy in an effort to prevent hair loss as a result of cancer treatments. Researchers based at The University of Manchester have discovered a new strategy for how to protect hair follicles from chemotherapy, which could lead to new treatments that prevent chemotherapy-induced hair loss — arguably one […]

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Patients taking nivolumab experience five-fold increase in overall survival compared to chemotherapy: Five-year outcomes from the randomized, phase 3 trials checkmate 017/057: nivolumab vs. docetaxel in previously treated NSCLC

Pooled data on two clinical trials demonstrate patients taking nivolumab realized a greater than five-fold increase in five-year overall survival rate compared with the chemotherapy docetaxel. The presentation was made today by Dr. Scott Gettinger of Yale Comprehensive Cancer Center, New Haven, Conn., at the IASLC 2019 World Conference on Lung Cancer, hosted by the International Association for the Study […]

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Possible new treatment strategy for lung cancer: Combination therapy targeting KRAS mutation could provide benefit to nearly a third of lung cancer patients

Lung cancer is the second most common cancer found in both men and women. It is estimated there will be roughly 228,000 new lung cancer cases this year, and nearly 30% of those patients will have mutations in the KRAS pathway. This type of mutation makes the cancer more aggressive and difficult to treat. Researchers at Moffitt Cancer Center are […]

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Better tools, better cancer immunotherapy

In the journal Science Immunology, researchers from DTU Health Technology and Jacobs University in Bremen have just published their cutting-edge research demonstrating advancement in detection of a certain type of immune cells, called T cells. Improved detection of T cells have several therapeutic implications. For example, in cancer immunotherapy (a therapeutic approach that engage patients own immune cells) characterization of […]

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Researchers unlock cancer cells’ feeding mechanism, central to tumor growth: The findings could lead to new treatments by blocking tumor growth at its roots

An international team led by researchers from the University of Cincinnati and Japan’s Keio and Hiroshima universities has discovered the energy production mechanism of cancerous cells that drives the growth of the nucleolus and causes tumors to rapidly multiply. The findings, published Aug. 1 in the journal Nature Cell Biology, could lead to the development of new cancer treatments that […]

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Low level exposure to air pollution is harmful, mouse model shows

Air pollution is made up of both gaseous and particulate matter (PM). Each year almost two million people die as a direct result of air pollution with many more experiencing impaired lung function, developing lung diseases such as asthma and chronic obstructive pulmonary disease (COPD). However research, on the effects of low level air pollution, is often overlooked. An international […]

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Evidence a cancer drug may be extended to many more patients

A new molecular mechanism discovered by UT Southwestern researchers indicates that drugs currently used to treat less than 10 percent of breast cancer patients could have broader effectiveness in treating all cancers where the drugs are used, including ovarian and prostate cancers. The new study also revealed a potential biomarker indicating when these drugs, called PARP inhibitors, can be unleashed […]

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