Micro-control of liver metabolism

Researchers at TIFR have discovered molecular anticipation of feeding in the liver that is essential to ensure that the body, after fasting, adapts to utilize incoming nutrients upon re-feeding. Their findings, published in the international journal Cell Reports, show that very small RNA molecules called microRNAs control major metabolic pathways by inhibiting synthesis of proteins, and thus contribute to maintenance […]

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Bad cholesterol: ‘Slim down’ fat-carrying particles to reduce its spread

The enzyme that ‘loads up’ fat-carrying particles in the liver before they are transported around the body has been identified for the first time by scientists at the University of Warwick. The discovery also reveals how to ‘slim down’ these particles to reduce the amount of the worst type of ‘bad’ cholesterol distributed throughout the body and could pave the […]

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Diet low in added sugars significantly improves fatty liver disease in children

A randomized clinical study of adolescent boys with nonalcoholic fatty liver disease (NAFLD) found that a diet low in free sugars (those sugars added to foods and beverages and occurring naturally in fruit juices) resulted in significant improvement in NAFLD compared to a usual diet. The study was conducted at Emory University School of Medicine and the University of California […]

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Health effects of metabolic ‘magic bullet’ protein: New model lets scientists activate health-promoting enzyme AMPK at any time and in any tissue

The metabolic protein AMPK has been described as a kind of magic bullet for health. Studies in animal models have shown that compounds that activate the protein have health-promoting effects to reverse diabetes, improve cardiovascular health, treat mitochondrial disease — even extend life span. However, how much of the effects of these compounds can be fully attributed to AMPK versus […]

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