First comprehensive structural data on a key flu protein—it’s central to infection

Influenza A viruses spawn epidemics, global pandemics and sweeping outbreaks that kill millions of birds, yet only now have flu scientists obtained comprehensive, high-resolution structural data on a protein that is key to the very survival of an influenza virus. The highlighted protein is RNA polymerase, which transcribes and replicates the viral genome in the nucleus of host cells. Dr. […]

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SIRT1 plays key role in chronic myeloid leukemia to aid persistence of leukemic stem cells

Patients with chronic myeloid leukemia can be treated with tyrosine kinase inhibitors. While these effective drugs lead to deep remission and prolonged survival, primitive leukemia stem cells resist elimination during the remission and persist as a major barrier to cure. As a result, the majority of patients with chronic myeloid leukemia, or CML, require indefinite inhibitor treatment to prevent disease […]

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Mutual appreciation key to saving marriage after a stroke, study shows

Laurel Sproule knew something in her 18-year marriage was changing when she came into the kitchen and found her husband Fred just standing there. He’d suffered a recent heart attack and then a stroke, but was home, and slowly responding to therapy. Getting ready to go out one day, they needed to eat lunch first, so Laurel laid out sandwich […]

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Computer hardware originally designed for 3-D games could hold the key to replicating the human brain

Researchers at the University of Sussex have created the fastest and most energy efficient simulation of part of a rat brain using off-the-shelf computer hardware. Dr. James Knight and Prof Thomas Nowotny from the University of Sussex’s School of Engineering and Informatics have beaten a top 50 supercomputer by running brain simulations using their own GeNN software and graphics processing […]

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These bacteria may be the key to treating clinical depression

We like to think of ourselves as individuals. But scientists estimate that we share our bodies with 38 trillion organisms that play an integral part in keeping us healthy and making us who we are. They crawl across our skin, cling to our intestines, and generally call our bodies home. Now, a study led by researchers at Northeastern shows that […]

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On the trail of rare genetic disease, scientists uncover key immune regulator

Scientists at Scripps Research have found an important immune system-regulating protein that in principle could be targeted to treat cancers and chronic viral infections. The scientists, in a study published November 12 in Nature Chemical Biology, set out to determine the function of a protein, ABHD12, whose absence causes a rare genetic disease featuring a host of brain and nerve […]

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Key Strategies When Caring for a Loved One With Dementia

SUNDAY, Nov. 25, 2018 — People caring for a loved one with Alzheimer’s or other types of dementia should focus on four main safety issues, an expert says. Nearly 6 million Americans have Alzheimer’s disease, according to the Alzheimer’s Association. About 16.1 million Americans provide unpaid care for people with Alzheimer’s or other dementias. “When approaching dementia families, I follow […]

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