Ketamine isn’t an opioid and treats depression in a unique way

Ketamine has gotten a bad rap as an opioid when there’s plenty of evidence suggesting it isn’t one, Johns Hopkins experts say. They believe this reputation may hamper patients from getting necessary treatment for the kinds of depression that don’t respond to typical antidepressants. In a new paper, the researchers clarify the mechanism behind ketamine’s mechanism of action in hopes […]

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New drug mimics benefits of ketamine for depression

A new small-molecule drug produced a rapid antidepressant response similar to that of ketamine when tested in mice, a new Yale-led study published April 16 in the Journal of Clinical Investigation shows. The effects of the drug, called NV-5138, in rodent models mimicked the rapid actions of the anesthetic ketamine, a variation of which, Esketamine, was recently approved by the […]

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Many say ketamine eased their depression, but is it safe?

Jen Godfrey (HealthDay)—Jen Godfrey couldn’t shake the “deep cloud” that lingered even after she found an antidepressant she could tolerate. Then a string of stressors hit—five years of fertility treatment and an 80-pound weight gain during pregnancy that left her with persistent pain; a close relative’s suicide; another who went missing; and her own divorce. It was all too much […]

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