Muscle stem cells can drive cancer that arises in Duchenne muscular dystrophy

People with Duchenne muscular dystrophy (DMD) can develop an otherwise-rare muscle cancer, called rhabdomyosarcoma, due to the muscle cells’ continuous work to rebuild the damaged tissue. However, little is known about how the cancer arises, hindering development of a treatment or test that could predict cancer risk. Now, scientists from Sanford Burnham Prebys Medical Discovery Institute (SBP) have demonstrated that […]

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New report reveals stark north-south divide in painkiller prescribing in England

A new report has revealed that patients in the north of the country are being prescribed almost four times more opioids to relieve pain than those in the south. The research by the University of Nottingham’s School of Pharmacy and the University of Manchester is the first national study to examine the regional variations in opioid prescribing and how this […]

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Activated PMN exosomes are pathogenic entities that cause destruction in the COPD lung

University of Alabama at Birmingham researchers have found a novel, previously unreported pathogenic entity that is a fundamental link between chronic inflammation and tissue destruction in the lungs of patients with chronic obstructive pulmonary disease, or COPD. COPD is the fourth-leading cause of death in the world. This pathogenic entity—exosomes from activated polymorphonuclear leukocytes, or PMNs—caused COPD damage when the […]

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Persistent Opioid Use High in Head, Neck Cancer Patients

FRIDAY, Jan. 11, 2019 — Persistent opioid use at three and six months remains high among patients undergoing treatment for head and neck squamous cell cancer, according to a study recently published in Otolaryngology-Head and Neck Surgery. Jessica D. McDermott, M.D., from the University of Colorado Anschutz School of Medicine in Aurora, and colleagues used data from the Surveillance, Epidemiology […]

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Thyroid Surgery Complications Can Land Some Back in the Hospital

TUESDAY, Jan. 8, 2019 — Surgery to remove all or part of the thyroid can trigger side effects that send some patients back to the hospital, a new study finds. These side effects include tingling in the fingers that can become tremors and spasms in all muscles of the body — including the heart and muscles surrounding the lungs. “The […]

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Role of PCSK9 inhibitors in high risk patients with dyslipidemia

Familial hypercholesterolemia (FH) is an inherited autosomal dominant disorder which is characterized by substantially increased Low-Density Lipoprotein Cholesterol (LDL-C) levels. Timely reduction of LDL-C is of paramount importance to ameliorate the risk for CV disease as patients with FH have a significantly higher risk for Cardiovascular (CV) events. Pro-protein Convertase Subtilisin/Kexin type 9 (PCSK9) inhibitors have emerged as a very […]

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Building passion when you’re not in love with your job

(HealthDay)—Here’s some career advice for the new year. Experts often suggest that people follow their passion when looking for work that they’ll feel enriched by. But sometimes you don’t have a choice and have to take a job that you’re not quite wild about, to put it mildly. But rather than feel resentful and unhappy every day, over time you […]

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