CAR T cell therapy: On the cusp of ‘an immunotherapy revolution’?

A deeper understanding of the immune system’s role in controlling cancer has helped drive “an immunotherapy revolution,” offering hope for many patients with previously incurable cancers, including children, doctors have concluded in a new report. The assessment, from two Stanford University doctors, is part of their broader analysis on lessons learned from “the first leg of the CAR T cell […]

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Encephalitis identified as rare toxicity of immunotherapy treatment

After a cancer patient receiving an immunotherapy developed encephalitis and died 18 months into treatment, researchers at Vanderbilt-Ingram Cancer Center (VICC) investigated why the complication occurred, performing a molecular analysis of the disease’s pathology and mining data to determine the incidence of similar occurrences. The molecular analysis revealed the presence of T cells known to react to Epstein-Barr virus in […]

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Bacteria engineered as Trojan horse for cancer immunotherapy

The emerging field of synthetic biology—designing new biological components and systems—is revolutionizing medicine. Through the genetic programming of living cells, researchers are creating engineered systems that intelligently sense and respond to diverse environments, leading to more specific and effective solutions in comparison to current molecular-based therapeutics. At the same time, cancer immunotherapy—using the body’s immune defenses to fight cancer—has transformed […]

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Study may explain why immunotherapy not effective for some patients with metastatic melanoma and kidney cancer

White blood cells known as B cells have been shown to be effective for predicting which cancer patients will respond to immune checkpoint blockade (ICB) therapy, according to a study at The University of Texas MD Anderson Cancer Center. Study results will be presented April 2 at the AACR Annual Meeting 2019 in Atlanta. The study, led by Jennifer Wargo, […]

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Dietary factors affecting gut microbiome may influence response to immunotherapy in melanoma patients

Among melanoma patients treated with anti-PD-1 immunotherapy, consumption of a high-fiber diet was associated with higher gut microbiome diversity and better response to treatment, according to data presented during a media preview of the AACR Annual Meeting 2019, to be held March 29-April 3 in Atlanta. “We found that diet and supplements appear to have an effect on a patient’s […]

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Study shows immunotherapy drug helps patients with metastatic melanoma

When melanoma turns metastatic, it spreads to the brain in more than 40% of patients. A study by Yale Cancer Center researchers published today in the Journal of Clinical Oncology (JCO) shows a checkpoint inhibitor immunotherapy drug has meaningful benefit for these patients. The study is one of the first clinical trials aimed at treating the brain metastases with this […]

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