Undiplomatic immunity: Mutation causing arterial autoimmune disease revealed

Takayasu arteritis is a disease that mainly affects female Asians at a relatively young age. It involves chronic inflammation of the aorta, and potentially leads to fatal disruption of the structures through which blood flows from the heart. Although studies have suggested a genetic component to this disease, its mechanisms have remained opaque until now. A new study led by […]

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Immunity connects gut bacteria and aging

Over the years, researchers have learned that the different populations of bacteria that inhabit the gut have significant effects on body functions, including the immune system. The populations of gut bacteria are sometimes called “commensal,” and exist in virtually all animals living under a certain functional balance. When this balance is disrupted—for example, because of disease or medication—it gives rise […]

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Small populations of normal cells affect immunity in patients with XLP1

Human SH2D1A mutations resulting in X-linked lymphoproliferative syndrome type 1 (XLP1) are associated with a unique susceptibility to the Epstein-Barr virus (EBV), which may lead to fatal infectious mononucleosis (FIM). Many studies have attempted to elucidate an appropriate treatment for XLP1 that does not involve hematopoietic stem cell transplantation (HSCT); clinical evidence supporting such treatments has been minimal, until now. […]

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