The type of fast you do could matter to your immune system

Those interested in fasting, to boost their health or lose a little belly fat, are not starved for choice. As the trend has grown in popularity, so too have the number of ways in which we can do it. There’s the 16:8, the 5:2, the fast 800, alternate-day fasting, fast "mimicking" and the eat-stop-eat 24-hour fast. But not all types […]

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A genomic barcode tracker for immune cells

Researchers from the Garvan Institute of Medical Research have developed a new method to spot rare immune cells that are reactive against cancer cells, from within a patient’s own immune system. The patented ‘RAGE-seq’ method enables scientists to track how immune cells evolve inside tumour tissue for the first time, revealing unprecedented insight into how to better arm the immune […]

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Holes in the immune system left unrepaired despite drug therapy

If they don’t receive antiretroviral therapy (ART), most HIV patients see a progressive weakening of their immune system. But a very small percentage of patients—0.3%—spontaneously control the virus themselves, without ART. Could an explanation lay partly in the sets of genes expressed by scarce white blood cells that recognize HIV? Yes, according to a study published in Nature Immunology and […]

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Innate immune responses to high-fat diets lead to obesity

Why is eating a high fat diet a recipe for obesity? According to a new study from the RIKEN Center for Integrative Medical Sciences (IMS) in Japan, the answer involves the activity of a specific type of immune cell that lives in the small intestine. Published in the journal Cell Reports, a series of experiments shows that without group-2 innate […]

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Detailed brain map uncovers hidden immune cells that may be involved in neurodegenerative disorders

Brains contain a variety of immune cells that play an important role for brain function. A team led by Prof. Kiavash Movahedi (VIB Center for Inflammation Research at VUB) has developed a comprehensive cell atlas of the brain’s immune compartment. This revealed not only the striking diversity of brain macrophages, but also uncovered microglia where they were not expected. Remarkably, […]

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Researchers discover how tumor-killing immune cells attack lymphomas in living mice

In a study that will be published April 1 in the Journal of Experimental Medicine, researchers from the Institut Pasteur and INSERM reveal that chimeric antigen receptor (CAR) T cells can induce tumor regression by directly targeting and killing cancer cells, uncovering new details of how these immune cells work and how their effectiveness could be improved in the treatment […]

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Doctors and molecular engineers working to enlist the immune system to fight cancer

When telling the story of immunotherapy and cancer and how the two battle it out, it’s awfully challenging not to pull out the old A Tale of Two Cities cliché. Because everyone agrees: It is the best of times in cancer research and treatment. Over the past five years, the standard of care for treatment of many cancers has made […]

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Eating a Western diet makes you more prone to listeria

How eating a Western diet makes you more prone to listeria: Menu of pizza, burgers and chips makes the immune system less able to fight the deadly infection Diet altered the gut bacteria of mice, therefore their susceptibility to infection  Listeria is found in contaminated food and can cause serious problems The diet also caused inflammation supporting previous evidence e-mail View […]

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argenx Provides Detailed Data from Phase 2 Clinical Trial of Efgartigimod in Immune Thrombocytopenia and Phase 1/2 Clinical Trial of Cusatuzumab in Acute Myeloid Leukemia

Breda, the Netherlands / Ghent, Belgium – December 03, 2018 — argenx (Euronext & Nasdaq: ARGX), a clinical-stage biotechnology company developing a deep pipeline of differentiated antibody-based therapies for the treatment of severe autoimmune diseases and cancer, today announced  that it will share the detailed data from its Phase 2 clinical trial of efgartigimod (ARGX-113) in immune thrombocytopenia (ITP)  and […]

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On the trail of rare genetic disease, scientists uncover key immune regulator

Scientists at Scripps Research have found an important immune system-regulating protein that in principle could be targeted to treat cancers and chronic viral infections. The scientists, in a study published November 12 in Nature Chemical Biology, set out to determine the function of a protein, ABHD12, whose absence causes a rare genetic disease featuring a host of brain and nerve […]

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