Immune cells in skin kill MRSA bacteria before they enter the body

A type of immune cell called neutrophils could be responsible for controlling bacterial numbers of an antibiotic-resistant strain of Staphylococcus aureus (MRSA) on human skin before the bacteria get a chance to invade, according to a new study from Karolinska Institutet published in Cell Reports. The results could provide an explanation for why this superbug is only carried transiently by […]

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The night gardeners: Immune cells rewire, repair brain while we sleep

Science tells us that a lot of good things happen in our brains while we sleep—learning and memories are consolidated and waste is removed, among other things. New research shows for the first time that important immune cells called microglia—which play an important role in reorganizing the connections between nerve cells, fighting infections, and repairing damage—are also primarily active while […]

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Using the immune system as a defence against cancer

Research published today in the British Journal of Cancer has found that a naturally occurring molecule and a component of the immune system that can successfully target and kill cancer cells, can also encourage immunity against cancer resurgence. Several teams led by Professor Livio Mallucci from King’s College London discovered that β-galactoside-binding protein (βGBP), a naturally occurring molecule produced by […]

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Bacteria injections help the immune system fight cancer

Cancers evade destruction by convincing some immune cells to suppress others. But a surprising interlocutor can persuade the suppressors to defect, and the destroyers to redouble. A review published in Frontiers in Oncology explains how bacteria can rally immune cells to attack tumors, via ancient lines of chemical communication with our immune system. Decoding these molecular signals is key to […]

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The type of fast you do could matter to your immune system

Those interested in fasting, to boost their health or lose a little belly fat, are not starved for choice. As the trend has grown in popularity, so too have the number of ways in which we can do it. There’s the 16:8, the 5:2, the fast 800, alternate-day fasting, fast "mimicking" and the eat-stop-eat 24-hour fast. But not all types […]

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A genomic barcode tracker for immune cells

Researchers from the Garvan Institute of Medical Research have developed a new method to spot rare immune cells that are reactive against cancer cells, from within a patient’s own immune system. The patented ‘RAGE-seq’ method enables scientists to track how immune cells evolve inside tumour tissue for the first time, revealing unprecedented insight into how to better arm the immune […]

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Holes in the immune system left unrepaired despite drug therapy

If they don’t receive antiretroviral therapy (ART), most HIV patients see a progressive weakening of their immune system. But a very small percentage of patients—0.3%—spontaneously control the virus themselves, without ART. Could an explanation lay partly in the sets of genes expressed by scarce white blood cells that recognize HIV? Yes, according to a study published in Nature Immunology and […]

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Innate immune responses to high-fat diets lead to obesity

Why is eating a high fat diet a recipe for obesity? According to a new study from the RIKEN Center for Integrative Medical Sciences (IMS) in Japan, the answer involves the activity of a specific type of immune cell that lives in the small intestine. Published in the journal Cell Reports, a series of experiments shows that without group-2 innate […]

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Detailed brain map uncovers hidden immune cells that may be involved in neurodegenerative disorders

Brains contain a variety of immune cells that play an important role for brain function. A team led by Prof. Kiavash Movahedi (VIB Center for Inflammation Research at VUB) has developed a comprehensive cell atlas of the brain’s immune compartment. This revealed not only the striking diversity of brain macrophages, but also uncovered microglia where they were not expected. Remarkably, […]

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Researchers discover how tumor-killing immune cells attack lymphomas in living mice

In a study that will be published April 1 in the Journal of Experimental Medicine, researchers from the Institut Pasteur and INSERM reveal that chimeric antigen receptor (CAR) T cells can induce tumor regression by directly targeting and killing cancer cells, uncovering new details of how these immune cells work and how their effectiveness could be improved in the treatment […]

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