Kidney disease: Senescent cell burden is reduced in humans by senolytic drugs

In a small safety and feasibility clinical trial, Mayo Clinic researchers have demonstrated for the first time that senescent cells can be removed from the body using drugs termed “senolytics.” The result was verified not only in analysis of blood but also in changes in skin and fat tissue senescent cell abundance. The findings appear in the journal EBioMedicine. This […]

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Why HIV patients are more likely to develop tuberculosis: Discovery could lead to new added therapy for HIV patients

Tuberculosis and HIV — two of the world’s deadliest infectious diseases — are far worse when they occur together. Now, Texas Biomedical Research Institute researchers have pinpointed an important mechanism at work in this troubling health problem. And, their discovery could lead to a new mode of treatment for people at risk. The results were published in the Journal of […]

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Cellular processes controlling the formation of lymphatic valves: Targeting VE-cadherin signaling pathways holds promise for treating lymphedema’s debilitative swelling

Lymphedema, resulting from a damaged lymphatic system, can be a debilitating disease in which excess protein-rich fluid (lymph) collects in soft tissues and causes swelling — most often in the arms or legs. Symptom severity varies, but the chronic swelling can lead to pain, thickened skin, disfigurement, loss of mobility in affected limbs, and recurrent infections. While lymphedema can be […]

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What drives inflammation in type 2 diabetes? Not glucose, says new research

To date, the underlying causes of inflammation in obesity and type 2 diabetes mellitus (T2DM) have been poorly understood, which has hampered efforts to develop treatments to prevent complications from a disease that is the third leading cause of death in the United States. But new research at the University of Kentucky shows that changes to mitochondria — the powerhouse […]

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Human cells assembling into fractal-like clusters

Tree-like branching structures are everywhere in the human body, from the bronchial system in the lungs to the spidering capillaries that supply blood to the extremities. Researchers have long worked to understand the cellular signaling needed to build these intricate structures, but new research suggests that simple physics may play an underappreciated role. The research, published in the Proceedings of […]

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Better tools, better cancer immunotherapy

In the journal Science Immunology, researchers from DTU Health Technology and Jacobs University in Bremen have just published their cutting-edge research demonstrating advancement in detection of a certain type of immune cells, called T cells. Improved detection of T cells have several therapeutic implications. For example, in cancer immunotherapy (a therapeutic approach that engage patients own immune cells) characterization of […]

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High-risk pregnancy: The interferon effect: Discovery of a cellular mechanism involved in abnormal placental development during some high-risk pregnancies

High-risk pregnancies occur frequently and may be caused by various factors. It is estimated that 10 to 20% of pregnant women miscarry during their first trimester of pregnancy. Slow fetal growth may also arise as a result of maternal infection with certain microbes, parasites or viruses (such as toxoplasmosis or infection with rubella virus, cytomegalovirus, herpes or Zika) or because […]

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Superbug virulence regulatory mechanism revealed: Pave ways for developing new antibiotics

As antibiotic resistance is growing and posing a threat on public health, developing new antibiotics has become more urgent than ever. Researchers at City University of Hong Kong (CityU) have recently revealed the virulence regulatory mechanism in Pseudomonas aeruginosa, a superbug which is common in patients with a weak immune system and is resistant to many antibiotics. The findings pave […]

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Scientists eliminate HIV from animal’s genome for the first time; indicate possible cure for HIV

Current HIV treatment focuses on the use of antiretroviral therapy (ART). ART suppresses HIV replication but does not eliminate the virus from the body. Therefore, ART is not a cure for HIV, and it requires life-long use. For the first time, researchers have eliminated replication-competent HIV-1 DNA — the virus responsible for AIDS — from the genomes of living animals. […]

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