Toxin responsible for Legionella growth identified

A team of scientists led by EMBL group leader Sagar Bhogaraju and Ivan Dikic of Goethe University, Frankfurt, discovered that the toxin SidJ in Legionella bacteria enforces a unique modification on human proteins and helps legionella grow inside human cells. SidJ hijacks human protein Calmodulin to its own advantage in one of the classic examples of pathogenic bacteria exploiting the […]

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Encephalitis identified as rare toxicity of immunotherapy treatment

After a cancer patient receiving an immunotherapy developed encephalitis and died 18 months into treatment, researchers at Vanderbilt-Ingram Cancer Center (VICC) investigated why the complication occurred, performing a molecular analysis of the disease’s pathology and mining data to determine the incidence of similar occurrences. The molecular analysis revealed the presence of T cells known to react to Epstein-Barr virus in […]

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Mechanism of impaired wound healing in diabetes identified

Researchers at Karolinska Institutet in Sweden have identified a mechanism that can explain the impaired wound healing in diabetes which can lead to diabetic foot ulcers. The study is published in the scientific journal Proceedings of the National Academy of Sciences. In diabetic mice, wound healing improved when the identified signalling pathway was blocked. Diabetic foot ulcerations are a common […]

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Risk factors identified for late recurrence of liver cancer

(HealthDay)—Late recurrence after hepatocellular carcinoma (HCC) resection is associated with sex, cirrhosis, and several aggressive tumor characteristics of the initial HCC, according to a study recently published in JAMA Surgery. Xin-Fei Xu, M.D., from Second Military Medical University in Shanghai, and colleagues examined risk factors, patterns, and outcomes of late recurrence (more than two years) after curative liver resection for […]

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Gene vital for post-stroke recovery identified for the first time

Having certain specific variants of the PATJ gene predisposes ischemic stroke victims for worse recovery. Seven out of 10 patients with these variants suffer severe sequelae three months after having a stroke and are thus placed in a situation of medical dependence, compared to less than half of patients who do not present these variants. This is according to data […]

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