Laboratory studies identify a potential way to treat human cancers with ARID1A mutations

A new study shows that tumor cells depleted of ARID1A—a protein that acts as a cancer suppressor—become highly sensitive to anticancer poly ADP ribose polymerase (PARP) inhibitor drugs after radiation treatment. The research, led by Johns Hopkins Kimmel Cancer Center researchers, could advance efforts to treat many human cancers with loss of ARID1A that are resistant to current standard treatments, […]

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Gene protective against fruit fly heat-induced seizures may explain some human seizures

Researchers identified a gene in fruit flies that helps prevent the hyperexcitability of specific neurons that trigger seizures. In humans, mutations in the gene may be linked to seizures associated with Long QT Syndrome. A research team led by Yehuda Ben-Shahar of Washington University in St. Louis report these findings in a paper published 8th August in PLOS Genetics. The […]

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Jeffrey Epstein was devising plan to seed the human race with his DNA

Jeffrey Epstein was devising a plan to seed the human race with his DNA by impregnating women at his New Mexico ranch and wanted to have his penis and head frozen after he died Jeffrey Epstein planned to have 20 women at a time impregnated on in Santa Fe ranch, sources told the Times The moneyman claimed to spend $20 […]

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Pigs help scientists understand human brain

For the first time, researchers in the University of Georgia’s Regenerative Bioscience Center have used an imaging method normally reserved for humans to analyze brain activity in live agricultural swine models, and they have discovered that pig brains are even better platforms than previously thought for the study of human neurological conditions such as Alzheimer’s and Parkinson’s. One immediate potential […]

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Better human rights protections around the world for people with disabilities, but gaps remain

The first comprehensive human rights treaty of the 21st century, the Convention on the Rights of Persons with Disabilities (CRPD) stands as one of the most quickly ratified human rights treaties in history. Globally, according to the United Nations (UN), approximately four billion people are affected by disability policy—including one billion persons with disabilities, one billion who are aging and […]

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Snout dated: Slow-evolving elephant shark offers new insights into human physiology

The mineralocortoid receptor (MR) regulates water and sodium transport throughout cells and tissues, which is critical for controlling blood pressure and so, not surprisingly, the MR is common to all vertebrate animals. Aldosterone, which is a physiological steroid for land vertebrate MRs, evolved in lungfish (forerunners of land vertebrates), suggesting that the evolution of aldosterone was important in the conquest […]

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Human antibody reveals hidden vulnerability in influenza virus

The ever-changing “head” of an influenza virus protein has an unexpected Achilles heel, report scientists funded by the National Institute of Allergy and Infectious Diseases (NIAID), one of the National Institutes of Health. The team discovered and characterized the structure of a naturally occurring human antibody that recognizes and disrupts a portion of the hemagglutinin (HA) protein that the virus […]

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Computational model of a human kinase may provide insights for cancer treatment

Researchers have developed a computational model for human MEK1, a protein with potential as a drug target for a variety of human cancers. The initiation and progression of cancer cells occur when molecular signals involved in cellular proliferation go awry. MEK1 plays an essential role in signaling within both healthy and cancer cells. While much is known about the key […]

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Adults at high risk for HIV infection have low rates of vaccination against human papillomavirus

Adults who are at high risk of becoming infected with the human immunodeficiency virus (HIV), which causes AIDS, were less likely than the general population to be vaccinated against human papillomavirus (HPV), which can cause anal and cervical cancer, according to results presented at the AACR Annual Meeting 2019, held in Atlanta March 29-April 3. HPV infection is common, and […]

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Scientists find first evidence for necessary role of the human hippocampus in planning

A team of scientists reports finding the first evidence that the human hippocampus is necessary for future planning. Its findings, published in the journal Neuron, link its long-established role in memory with our ability to use our knowledge to map out the future effects of our actions. The results have implications for the way we think about afflictions that affect […]

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