Metals influence C-peptide hormone related to insulin: New field of metalloendocrinology explores subtle effects of metals in body

Metals such as zinc, copper and chromium bind to and influence a peptide involved in insulin production, according to new work from chemists at the University of California, Davis. The research is part of a new field of “metalloendocrinology” that takes a detailed look at the role of metals in biological processes in the body. “We’re asking questions people didn’t […]

Read more

New computational tool improves gene identification

Like finding a needle in a haystack, identifying genes that are involved in particular diseases can be an arduous and time consuming process. Looking to improve this process, a team led by researchers at Baylor College of Medicine has developed a new bioinformatics tool that analyzes CRISPR pooled screen data and identifies candidates for potentially relevant genes with greater sensitivity […]

Read more

Chemical modifiers tag-team to regulate essential mechanism of life: Basic science discovery explains a fundamental way human cells differ from yeast cells

Scientists at the Gladstone Institutes have made a key observation about one of the most fundamental biological processes: gene transcription. A gene’s job is to provide a cell with the instructions to create a specific protein. The first step of this process is called transcription, during which the DNA is copied into RNA. The scribe is an enzyme called RNA […]

Read more

Research implicates causative genes in osteoporosis, suggesting new targets for future therapy: Innovative functional genomics tools likely to aid discovery in other genetic diseases

Scientists have harnessed powerful data analysis tools and three-dimensional studies of genomic geography to implicate new risk genes for osteoporosis, the chronic bone-weakening condition that affects millions of people. Knowing the causative genes may later open the door to more effective treatments. “Identifying a disease’s actual underlying cause often helps to steer us toward correct, targeted treatments,” said study leader […]

Read more

Narwhals spend at least half time diving for food, can fast for several days after meal: Tracking data from male Narwhal shows whales regularly dive to depths of over 700m

Narwhals — enigmatic arctic whales known for their sword-like tusk — spend over half their time diving to find food but are also able to last up to three days without a meal, according to a study by Manh Cuong Ngô and colleagues from the University of Copenhagen in Denmark, published in PLOS Computational Biology. Narwhals are deep-diving whales that […]

Read more

How viruses outsmart their host cells: Scientists decipher protein structure after more than fifty years of research

Viruses depend on host cells for replication, but how does a virus induce its host to transcribe its own genetic information alongside that of the virus, thus producing daughter viruses? For decades, researchers have been studying a type of bacteriophage known as ‘lambda’ to try and find an answer to this question. Using high-resolution cryo-electron microscopy, a research group from […]

Read more

Micro-control of liver metabolism

Researchers at TIFR have discovered molecular anticipation of feeding in the liver that is essential to ensure that the body, after fasting, adapts to utilize incoming nutrients upon re-feeding. Their findings, published in the international journal Cell Reports, show that very small RNA molecules called microRNAs control major metabolic pathways by inhibiting synthesis of proteins, and thus contribute to maintenance […]

Read more

Method to ‘turn off’ mutated melanoma: New study provides novel insights into the pathogenesis and treatment of NRAS mutant melanoma

Melanoma is the deadliest form of skin cancer and notorious for its resistance to conventional chemotherapy. Approximately 25 percent of melanoma is driven by oncogenic mutations in the NRAS gene, making it a very attractive therapeutic target. However, despite decades of research, no effective therapies targeting NRAS have been forthcoming. For the first time, an international group of researchers has […]

Read more

Going for an MRI scan with tattoos? First prospective study on risk assessment

According to Weiskopf, Director at the Max Planck Institute for Human Cognitive and Brain Sciences in Leipzig (MPI CBS), .” ..the most important questions for us were: Can we conduct our studies with tattooed subjects without hesitation? What restrictions may exist? At the Wellcome Centre for Human Neuroimaging, part of Queen Square Institute of Neurology at University College in London, […]

Read more

Bioethicists call for more robust system of ethical governance in human gene-editing

University of Otago bioethicists are calling for a more robust system of ethical governance in human gene-editing in the wake of the Chinese experiment aiming to produce HIV immune children. In an opinion article in the latest issue of the Journal of Zhejian University-SCIENCE B, a major international journal based in China, Professor Jing-Bao Nie, Dr Simon Walker and Jing-ru […]

Read more
1 2