Why HIV patients are more likely to develop tuberculosis: Discovery could lead to new added therapy for HIV patients

Tuberculosis and HIV — two of the world’s deadliest infectious diseases — are far worse when they occur together. Now, Texas Biomedical Research Institute researchers have pinpointed an important mechanism at work in this troubling health problem. And, their discovery could lead to a new mode of treatment for people at risk. The results were published in the Journal of […]

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How chikungunya virus may cause chronic joint pain

A new method for permanently marking cells infected with chikungunya virus could reveal how the virus continues to cause joint pain for months to years after the initial infection, according to a study published August 29 in the open-access journal PLOS Pathogens by Deborah Lenschow of Washington University School of Medicine in St. Louis, and colleagues. According to the authors, […]

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Charcoal-based drug delivery system improves efficacy of common herpes drug

A study led by researchers from the University of Illinois at Chicago has found that combining acyclovir — a commonly prescribed topical herpes medication — with particles of activated carbon improves efficacy of the drug. This new approach allows for less frequent dosing and overall course of treatment while providing some protection from infection by the virus as well, opening […]

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Newly developed approach shows promise in silencing HIV infection

Researchers from The University of Texas Medical Branch at Galveston have discovered a new potential medication that works with an HIV-infected person’s own body to further suppress the ever present but silent virus that available HIV treatments are unable to combat. Although the potential new drug could complement the current HIV anti-retroviral therapy (ART) medications, it may also be possible […]

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Light pollution may be increasing West Nile virus spillover from wild birds

We’re in the midst of summertime mosquito bite season and cities across the country are reporting a heightened number of West Nile Virus (WNV) cases. The house sparrow is one of the most common carriers of WNV in urban areas. Mosquitos feed off the infected birds and spread the virus to humans. New research finds house sparrows exposed to artificial […]

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Superbug virulence regulatory mechanism revealed: Pave ways for developing new antibiotics

As antibiotic resistance is growing and posing a threat on public health, developing new antibiotics has become more urgent than ever. Researchers at City University of Hong Kong (CityU) have recently revealed the virulence regulatory mechanism in Pseudomonas aeruginosa, a superbug which is common in patients with a weak immune system and is resistant to many antibiotics. The findings pave […]

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Deadly tick-borne virus cured with experimental flu drug, in mice: Bourbon virus has sickened people in Kansas, Missouri, Oklahoma

Only a few cases of the newly discovered Bourbon virus have been reported, and two of them ended in death, partly because no specific treatments are available for the tick-borne illness. Now, researchers at Washington University School of Medicine in St. Louis have identified an experimental antiviral drug that cures mice infected with the potentially lethal virus. The drug, favipiravir, […]

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Immunotherapy drug found safe in treating cancer patients with HIV, study suggests: Researchers seek to break down HIV exclusions in cancer clinical trials

The results of a study led by physicians at Fred Hutchinson Cancer Research Center showed that patients living with HIV and one of a variety of potentially deadly cancers could be safely treated with the immunotherapy drug pembrolizumab, also known by its brand name, KEYTRUDA®. During an ASCO presentation concurrent with release of a study in JAMA Oncology, Fred Hutch […]

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Drug can reverse hyperactivity induced by parasitic infection

When rodents get infected by Toxoplasma gondii, the single-celled brain parasite that causes toxoplasmosis, they become hyperactive risk-takers. In findings published this week in mBio, researchers show for the first time that it’s possible to reverse that behavioral change. Surprisingly, the study also showed that the restoration of normal behavior resulted from reducing inflammation — and not from reducing the […]

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Copycat fungus deceives immune system and deactivates body’s response to infection

Fungus can imitate signals from our immune system and prevent our body from responding to infection, new research from the University of Sheffield has found. Life-threatening fungal infection is a major killer of people with immune system problems such as blood cancers, HIV infection or following organ transplant. The new study focused on one of the most dangerous infections for […]

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