Kidney disease: Senescent cell burden is reduced in humans by senolytic drugs

In a small safety and feasibility clinical trial, Mayo Clinic researchers have demonstrated for the first time that senescent cells can be removed from the body using drugs termed “senolytics.” The result was verified not only in analysis of blood but also in changes in skin and fat tissue senescent cell abundance. The findings appear in the journal EBioMedicine. This […]

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Promising treatment for an incurable, deadly kidney disease

A potential treatment for polycystic kidney disease — a genetic disorder that causes the kidneys to swell with multiple cysts and can eventually lead to organ failure — has shown promising results in animal testing. A study describing the drug’s development and testing appears today in Nature Communications. The study shows an approximately 50 percent reduction in kidney size in […]

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Typhoid toxin accelerates cell aging to enhance killer infection

Scientists have revealed how the typhoid toxin works to hijack DNA repair machines and accelerate the aging of cells, a breakthrough that could pave the way for new strategies to combat the killer disease. As part of the study, experts from the Department of Biomedical Science with support from the new Healthy Lifespan Institute at the University of Sheffield, infected […]

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Cellular processes controlling the formation of lymphatic valves: Targeting VE-cadherin signaling pathways holds promise for treating lymphedema’s debilitative swelling

Lymphedema, resulting from a damaged lymphatic system, can be a debilitating disease in which excess protein-rich fluid (lymph) collects in soft tissues and causes swelling — most often in the arms or legs. Symptom severity varies, but the chronic swelling can lead to pain, thickened skin, disfigurement, loss of mobility in affected limbs, and recurrent infections. While lymphedema can be […]

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Seeing it both ways: Visual perspective in memory: Recalling memories from first- or third-person can change how well you remember them over time

Think of a memory from your childhood. Are you seeing the memory through your own eyes, or can you see yourself, while viewing that child as if you were an observer? “If memory was simply an exact recollection of our experiences, one would think that we would recall our early memories from the first-person perspective,” said Peggy St Jacques, assistant […]

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Dizziness of unknown cause may be perception disorder: Perception disorders may throw those affected off balance

Many patients with functional dizziness look back on a long odyssey to numerous doctors, because no organic causes could be found. Now for the first time, an experiment at the Technical University of Munich (TUM) has identified possible causes of the disorder: problems with the processing of sensory-motor signals in the brain that resemble those associated with dizziness due to […]

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Alzheimer’s protein is likely held together with many weak chemical interactions: Model reveals new role for overlooked electron relationships

The chemical interactions that give proteins their shape may be weaker and more numerous than previously recognized. These weak connections provide a new way for researchers to understand proteins that cause disease and help them gain insights into the fundamentals of chemistry. Chemists at the University of Tokyo modeled the building blocks of the protein structure that causes Alzheimer’s disease, […]

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New gene linked to healthy aging in worms

People with the same lifespan do not necessarily have the same quality of life. As we live longer, extending quality of life — “healthspan” — is gaining importance. Scientists at the Okinawa Institute of Science and Technology Graduate University (OIST) have discovered a gene linked with healthy ageing in the roundworm C. elegans, shedding light on the genetics of healthspan. […]

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Body composition shown to affect energy spent standing versus sitting: Findings support increased standing time as a simple way to boost energy expenditure

A person’s body composition could influence the difference between the amount of energy they spend while sitting versus standing, according to new research published in the open-access journal PLOS ONE. Conducted by Francisco J. Amaro-Gahete of the University of Granada, Spain, and colleagues, this work adds to mounting evidence that more energy is expended while standing than while sitting or […]

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Young athletes may need one-year break after knee surgery

After surgical reconstruction of the anterior cruciate ligament, young athletes are now recommended to undergo at least a year’s rehab and thorough testing before resuming knee-strenuous sport. Research shows that those who return to sport relatively soon after surgery incur a highly elevated risk of a second ACL injury. “What’s absolutely essential is to let the rehab take time. Every […]

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