Gene involved in colorectal cancer also causes breast cancer

Rare mutations in the NTHL1 gene, previously associated with colorectal cancer, also cause breast cancer and other types of cancer. Researchers from Radboud university medical center, Leiden University Medical Center and the Princess Máxima Center in the Netherlands report this new multi-tumor syndrome, in collaboration with international colleagues, in Cancer Cell. Nicoline Hoogerbrugge, professor of Hereditary Cancer at Radboud university […]

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Using gene drives to control wild mosquito populations and wipe out malaria

What is the deadliest animal on earth? It’s a question that brings to mind fearsome lions, tigers, sharks and crocodiles. But the answer is an animal that is no more than 1 centimeter long. A few mosquito species, out of the thousands that populate different environments, are the deadliest animals on earth. Anopheles mosquitoes alone, transmit malaria through their bite […]

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Team uses gene editing to personalize clinical care for family with cardiomyopathy

A little over a year ago, a 65-year-old woman with severe hypertrophic cardiomyopathy—a condition in which the heart’s muscle becomes abnormally thick, potentially causing dangerous irregular heartbeats—had her genes sequenced before her first visit to the Penn Center for Inherited Cardiac Disease. In the sequence, the patient’s care team identified a variant in a gene called TNNT2, which is associated […]

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Salmonella, gene swapping and antibiotic resistance: Five questions with Sid Thakur

Sid Thakur is a professor of population health and pathobiology and the director of NC State’s and the College of Veterinary Medicine’s Global Health programs. He studies antibiotic resistance in Salmonella and how antibiotic resistant Salmonella affect food animal and human populations. In his latest work, Thakur compared the genomes of over 200 different strains of Salmonella, looking for genetic […]

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Brain responses to language in toddlers with autism linked to altered gene expression

An international team of scientists, led by researchers at the University of Cyprus and University of California San Diego School of Medicine, have identified a previously unknown, large-scale association between molecular gene expression activity in blood leukocyte cells and altered neural responses to speech in toddlers with autism as measured with functional magnetic resonance imaging (fMRI). The findings were published […]

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Gene vital for post-stroke recovery identified for the first time

Having certain specific variants of the PATJ gene predisposes ischemic stroke victims for worse recovery. Seven out of 10 patients with these variants suffer severe sequelae three months after having a stroke and are thus placed in a situation of medical dependence, compared to less than half of patients who do not present these variants. This is according to data […]

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Decrease in specific gene ‘silencing’ molecules linked with pediatric brain tumors

Experimenting with lab-grown brain cancer cells, Johns Hopkins Medicine researchers have added to evidence that a shortage of specific tiny molecules that silence certain genes is linked to the development and growth of pediatric brain tumors known as low-grade gliomas. A report of the findings was published this fall 2018 in Scientific Reports, and supports the idea of increasing levels […]

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