Gene levels could help predict prognosis for colorectal cancer

Levels of a gene that helps the immune system differentiate the good cells from the bad could be a good indicator of prognosis in people with colorectal cancers, Medical College of Georgia researchers report. Looking at 15 genes known to be associated with colorectal cancers—eight associated with lower survival rates and seven with higher—the researchers found that one gene, CCR4, […]

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Experts call for halt to CRISPR editing that allows gene changes to pass on to children

Remember the global outrage four months ago at world-first claims a researcher had used the gene editing tool CRISPR to edit the genomes of twin girls? The molecular scissors known as CRISPR (CRISPR/cas9 in full) allow scientists to modify DNA with high precision and greater ease than previous technologies. Now researchers from the USA, Europe, China and New Zealand have […]

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Researchers discover serotonin can regulate gene expression inside neurons

The brain chemical serotonin, a neurotransmitter long known for its role in passing signals between neurons in the brain, can also regulate expression of genes within neurons in an unexpected way, according to research conducted by neuroscientists at the Icahn School of Medicine at Mount Sinai and published on March 13 in the journal Nature. The discovery may help scientists […]

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Scientist identifies gene responsible for spread of prostate cancer

A Rutgers study has found that a specific gene in cancerous prostate tumors indicates when patients are at high-risk for the cancer to spread, suggesting that targeting this gene can help patients live longer. The study, which was published in the journal Nature Communications, identified the NSD2 gene through a computer algorithm developed to determine which cancer genes that spread […]

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Gene involved in colorectal cancer also causes breast cancer

Rare mutations in the NTHL1 gene, previously associated with colorectal cancer, also cause breast cancer and other types of cancer. Researchers from Radboud university medical center, Leiden University Medical Center and the Princess Máxima Center in the Netherlands report this new multi-tumor syndrome, in collaboration with international colleagues, in Cancer Cell. Nicoline Hoogerbrugge, professor of Hereditary Cancer at Radboud university […]

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Using gene drives to control wild mosquito populations and wipe out malaria

What is the deadliest animal on earth? It’s a question that brings to mind fearsome lions, tigers, sharks and crocodiles. But the answer is an animal that is no more than 1 centimeter long. A few mosquito species, out of the thousands that populate different environments, are the deadliest animals on earth. Anopheles mosquitoes alone, transmit malaria through their bite […]

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Team uses gene editing to personalize clinical care for family with cardiomyopathy

A little over a year ago, a 65-year-old woman with severe hypertrophic cardiomyopathy—a condition in which the heart’s muscle becomes abnormally thick, potentially causing dangerous irregular heartbeats—had her genes sequenced before her first visit to the Penn Center for Inherited Cardiac Disease. In the sequence, the patient’s care team identified a variant in a gene called TNNT2, which is associated […]

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Salmonella, gene swapping and antibiotic resistance: Five questions with Sid Thakur

Sid Thakur is a professor of population health and pathobiology and the director of NC State’s and the College of Veterinary Medicine’s Global Health programs. He studies antibiotic resistance in Salmonella and how antibiotic resistant Salmonella affect food animal and human populations. In his latest work, Thakur compared the genomes of over 200 different strains of Salmonella, looking for genetic […]

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Brain responses to language in toddlers with autism linked to altered gene expression

An international team of scientists, led by researchers at the University of Cyprus and University of California San Diego School of Medicine, have identified a previously unknown, large-scale association between molecular gene expression activity in blood leukocyte cells and altered neural responses to speech in toddlers with autism as measured with functional magnetic resonance imaging (fMRI). The findings were published […]

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Gene vital for post-stroke recovery identified for the first time

Having certain specific variants of the PATJ gene predisposes ischemic stroke victims for worse recovery. Seven out of 10 patients with these variants suffer severe sequelae three months after having a stroke and are thus placed in a situation of medical dependence, compared to less than half of patients who do not present these variants. This is according to data […]

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