Media overrepresent drug treatments for chronic pain

Media reports on chronic pain are focusing on treatments involving opioids and cannabis at the expense of best practice non-drug treatments, researchers have found. Chronic pain, defined as persistent or recurring pain present for more than three months, is the leading cause of disability worldwide and affects one in five New Zealanders. The researchers analyzed 240 news articles on chronic […]

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Study urges life-saving drug treatment to combat Ukraine’s HIV epidemic

Credit: Michael S. Helfenbein University researchers finds that scaling up use of methadone and buprenorphine—medications for treating opioid use disorder known as opioid agonist therapies (OATs)—could greatly reduce HIV transmission rates and prevent deaths in Ukraine, where the disease is epidemic among people who inject drugs. The study was published in The Lancet. Annual new HIV infections in Ukraine—home to […]

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Weight loss drug from the 90s 'could slash epileptic seizures by 75%'

Controversial weight loss drug pulled from sale in the 1990s over heart damage fears ‘cuts the number of seizures in children with a severe form of epilepsy’ Fenfluramine was found to make people develop leaky heart valves in high doses Doctors stopped using it in 1997 but it has been found to have brain benefits It could reduce seizures by […]

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Drug combination shows promise in preclinical models of triple negative breast cancer

Tumor volume in a preclinical model of triple negative breast cancer (TNBC) was reduced four times more when an experimental polo-like kinase 1 (PLK1) inhibitor was combined with a standard-of-care chemotherapeutic agent than when the agent was used alone. Hollings Cancer Center scientists at the Medical University of South Carolina reported these findings in PLOS ONE. TNBC disproportionately affects African […]

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New diagnostic techniques and drug may slow and even reverse cognitive decline from aging

A groundbreaking clinical approach has been developed combining new diagnostic techniques to detect a leaking blood-brain barrier (BBB) with a new anti-inflammatory drug that for the first time slows or reverses age-related cognitive decline. In two related studies published in the journal Science Translational Medicine, researchers from Ben-Gurion University of the Negev (BGU) and the University of California, Berkeley (UC) […]

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One-two punch drug combination offers hope for pancreatic cancer therapy

Scientists at Sanford Burnham Prebys Medical Discovery Institute have identified a combination of two anti-cancer compounds that shrank pancreatic tumors in mice—supporting the immediate evaluation of the drugs in a clinical trial. U.S. Food and Drug Administration (FDA)-approved versions of the compounds are used today to treat certain leukemias and solid tumors, including melanoma. The study was published in Nature […]

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Machine learning’s next frontier: Epigenetic drug discovery

Machine learning’s powerful ability to detect patterns in complex data is revolutionizing how we drive, how we diagnose disease and now, how we discover new drugs. Scientists at Sanford Burnham Prebys Medical Discovery Institute have developed a machine-learning algorithm that gleans information from microscope images—allowing for high-throughput epigenetic drug screens that could unlock new treatments for cancer, heart disease, mental […]

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Drug reduces risk of pneumonia in newborn mice

The underdeveloped lungs and immune systems of premature babies put them at high risk of potentially deadly pneumonia. Now, a study from Washington University School of Medicine in St. Louis has found, in mice, that an inhaled drug promotes the development of lung immunity and reduces the risk of pneumonia. The findings, published Aug. 14 in Science Advances, suggest that […]

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Immunotherapy drug could help women with aggressive breast cancer

Immunotherapy drug could halt the return of the ‘most aggressive form of breast cancer’ and ‘save thousands of lives’ Women with triple negative breast cancer were given the drug Keytruda  Keytruda was taken alongside chemo to shrink tumours before surgery More than 60% of the patients showed no sign of cancer after the operation An immunotherapy drug could prevent a […]

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Why a plan to lower prescription drug prices should not be piecemeal

Demand for prescription medications in the U.S. is at an all time high, given that 50% of adults have at least one chronic condition, and 25% have two or more. Sixty percent of the population, and 90% of Medicare beneficiaries have taken at least one prescription medication in the past month. Rising health care costs over time are leading to […]

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