New drug mimics benefits of ketamine for depression

A new small-molecule drug produced a rapid antidepressant response similar to that of ketamine when tested in mice, a new Yale-led study published April 16 in the Journal of Clinical Investigation shows. The effects of the drug, called NV-5138, in rodent models mimicked the rapid actions of the anesthetic ketamine, a variation of which, Esketamine, was recently approved by the […]

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Well-known drug has less risk for preterm delivery in PCOS

Metformin can halve the risk of late miscarriage and preterm births for women with polycystic ovary syndrome (PCOS). PCOS occurs in 10 to 15 percent of all women. The symptoms are irregular menstrual periods, increased levels of male sex hormones and small ovarian blisters. In addition, many women with PCOS are overweight. Women with PCOS also have an increased incidence […]

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Death trap knock-out drops: As dangerous Liquid Ecstasy is

Colorless and tasteless: K. o.-drops of Devastating harm. You can delete memories, involuntarily, and are extremely dangerous in combination with alcohol. In Nightclubs, knockout drops therefore be used as a date-rape drug. K. o.-drops can be fatal. A current case in which a 24-year-old man had the responsibility to negligent homicide and bodily injury proves. The district court of Bamberg […]

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A new model for heart valve disease drug discovery

An article published in Experimental Biology and Medicine describes a new model for heart valve physiology. The study, led by Dr. Carla Lacerda, from the Department of Chemical Engineering at Texas Tech University reports that 10% cyclic radial strain on isolated mitral valve anterior leaflets provides a true physiological environment that can be used for mechanistic studies and drug discovery. […]

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Drug delivery system would allow tuberculosis patients to switch from daily to monthly doses

Tuberculosis is one of the world’s deadliest infectious diseases: One-third of the world’s population is infected with TB, and more than 1 million people die from the disease every year. One reason TB is so pervasive is that treatment requires a six-month course of daily antibiotics, which is difficult for about half of all patients to adhere to, especially in […]

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New hope: German doctor to have discovered a cure for Alzheimer’s

A German scientist may have discovered a drug against dementia-diseases that can make the memory loss undo. Animal experiments with the new drug breakthrough results – a clinical study with Alzheimer’s patients. To show whether the active ingredient with the name Triple-Receptor Agonist, also shows in people’s success. 200 Alzheimer’s patients take part in the study in England, you get […]

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Self-destruction system in TB bacteria may lead to ‘perfect drug’

In the United States, more than 9,000 cases of tuberculosis (TB) occurred in 2017. Though the U.S. has one of the lowest TB rates worldwide, the disease remains one of the top 10 leading causes of death around the globe. In fact, the World Health Organization (WHO) estimate that approximately 10 million people had TB in 2017, and that 1.6 […]

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Study reveals patterns of drug intoxication deaths, organ donors across the US

Drug intoxication deaths have risen dramatically over the past several decades. From 1999 to 2016, the number of deaths due to drug intoxication more than tripled. Over the same period, the number of hearts recovered for heart transplantation has dramatically increased, with the proportion of hearts from drug-intoxication-related donors now making up 17.6 percent of available organs. Transplantation and cardiology […]

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Regulation and potential drug targets of tumor-associated Tregs

According to estimates from the World Health Organization (WHO), there will be 18.1 million new cases and 9.6 million cancer deaths worldwide in 2018. Cancer is a serious disease that affects people all over the world. And studies on the treatment of tumors have far-reaching significance. In recent years, tumor immunotherapy has become the fourth-ranking cancer treatment measure in line […]

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