Holes in the immune system left unrepaired despite drug therapy

If they don’t receive antiretroviral therapy (ART), most HIV patients see a progressive weakening of their immune system. But a very small percentage of patients—0.3%—spontaneously control the virus themselves, without ART. Could an explanation lay partly in the sets of genes expressed by scarce white blood cells that recognize HIV? Yes, according to a study published in Nature Immunology and […]

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Discovery of mechanism behind precision cancer drug opens door for more targeted treatment

New research that uncovers the mechanism behind the newest generation of cancer drugs is opening the door for better targeted therapy. PARP inhibitors are molecular targeted cancer drugs used to treat women with ovarian cancer who have the BRCA1 and BRCA2 gene mutations. The drugs are showing promise in late-stage clinical trials for breast cancer, prostate cancer and pancreatic cancer […]

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Suit: Generic drug makers used code to fix price increases

A lawsuit says representatives of some of the nation’s largest generic drug manufacturers used code words to collude with competitors to divvy up market share and coordinate price increases. The code came in emails included in the lawsuit filed last month by attorneys general from more than 40 states. The 510-page federal lawsuit filed in Connecticut was released in full […]

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Anti hypertensive drug use was associated with a decreased dementia risk

Various clinical trials indicate what effects can be expected from standardized intervention programs on the basis of existing evidence. Little is known about the way in which such programs can be implemented in actual care practice. However, it may be possible to use data from clinical practice to estimate the potential of drug prescriptions to delay or reduce the development […]

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Health Canada’s drug safety warnings not consistent with other countries’: report

Health Canada needs to be more consistent with three other countries when it comes to issuing warnings about the safety risks of certain medications, especially if the jurisdictions with similar demographics have already advised patients taking the same drugs, a University of British Columbia professor says. Related Your drugs may have drugs in them: safety group finding meth in cocaine, […]

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Poll: Many blame drug firms for opioid crisis

About two-thirds of Americans believe drug companies are to blame for the opioid crisis, although nearly as many hold drug users themselves responsible, a new poll finds. The Associated Press-NORC Center for Public Affairs Research poll showed many people also fault doctors who prescribed opioid pain pills and government officials who haven’t done enough to expand addiction treatment and arrest […]

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New drug mimics benefits of ketamine for depression

A new small-molecule drug produced a rapid antidepressant response similar to that of ketamine when tested in mice, a new Yale-led study published April 16 in the Journal of Clinical Investigation shows. The effects of the drug, called NV-5138, in rodent models mimicked the rapid actions of the anesthetic ketamine, a variation of which, Esketamine, was recently approved by the […]

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Well-known drug has less risk for preterm delivery in PCOS

Metformin can halve the risk of late miscarriage and preterm births for women with polycystic ovary syndrome (PCOS). PCOS occurs in 10 to 15 percent of all women. The symptoms are irregular menstrual periods, increased levels of male sex hormones and small ovarian blisters. In addition, many women with PCOS are overweight. Women with PCOS also have an increased incidence […]

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Death trap knock-out drops: As dangerous Liquid Ecstasy is

Colorless and tasteless: K. o.-drops of Devastating harm. You can delete memories, involuntarily, and are extremely dangerous in combination with alcohol. In Nightclubs, knockout drops therefore be used as a date-rape drug. K. o.-drops can be fatal. A current case in which a 24-year-old man had the responsibility to negligent homicide and bodily injury proves. The district court of Bamberg […]

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