Experiments with roundworms suggest alternatives for the treatment of schizophrenia: Researchers used C. elegans as an animal model to investigate the importance of certain human genes for the treatment of schizophrenia.

A group of Brazilian scientists have long conducted experiments with roundworms to investigate the role of schizophrenia-linked genes in patients’ response to antipsychotic drugs. The results obtained thus far point to new ways of understanding resistance to certain classes of medication. The studies are conducted by researchers in the Pharmacology Department of the Federal University of São Paulo’s Medical School […]

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Bioengineers create ultrasmall, light-activated electrode for neural stimulation

Neural stimulation is a developing technology that has beneficial therapeutic effects in neurological disorders, such as Parkinson’s disease. While many advancements have been made, the implanted devices deteriorate over time and cause scarring in neural tissue. In a recently published paper, the University of Pittsburgh’s Takashi D. Y. Kozai detailed a less invasive method of stimulation that would use an […]

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A new hope in treating neurodegenerative disease

Alzheimer’s disease (AD) is the most representative degenerative brain disease, accounting for 60 to 80% of all dementia cases. In search for new mechanism for AD, the research team led by Professor Seong-Woon Yu of Brain and Cognitive Sciences paid attention to the autophagy of microglia, brain immune cells, is suppressed by inflammation. ‘Microglia’ are phagocytic immune cells which are […]

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Fear and anger had different effects on conservatives and liberals, study suggests

Fear and anger related to the 2016 presidential election and climate change, one of the campaign’s major issues, had different effects on the way conservatives and liberals processed information about the two topics, according to the results of a study by a University at Buffalo communication researcher. The findings, published in the journal Journalism & Mass Communication Quarterly, suggest that […]

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Long-term trauma outcomes heavily impacted by gender and education level

Trauma is a leading cause of disability in the world, resulting in more disability-adjusted life years than any other disease. While in-hospital, trauma-related mortality has decreased to just 4 percent in the U.S., little is known about what happens to the 96 percent of patients who survive their trauma injuries but may suffer debilitating long-term effects. Through the Functional Outcomes […]

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Brain activity shows development of visual sensitivity in autism

Research investigating how the brain responds to visual patterns in people with autism has shown that sensory responses change between childhood and adulthood. The differences observed between adult and young people mimicked those seen in a strain of fruit flies that had a genetic change associated with autism and other developmental conditions. This demonstrates that sensory issues in autism can […]

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Epileptics in high-crime neighborhoods have three times as many seizures

People with epilepsy living in high crime neighborhoods in Chicago had three times as many seizures as those living in neighborhoods with lower crime rates according to new research from the University of Illinois at Chicago presented at the American Epilepsy Society 2018 conference in New Orleans. Epilepsy is a chronic neurological disorder characterized by abnormal brain activity and seizures […]

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Microglia react distinctively during inflammation: LIH scientists provide new insights into function and heterogeneity of brain immune cells

The NorLux Neuro-Oncology Laboratory at LIH’s Department of Oncology conducts research on brain diseases, with a special emphasis on glioma biology, drug resistance and systems approaches. Within this research unit, Dr. Alessandro Michelucci focuses on the role of glial cells and inflammatory responses. Jointly with team member Dr. Carole Sousa and collaborating research groups from LIH and the University of […]

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Alcohol dependence, psychiatric disorders share genetic links: Key alcoholism gene influences how quickly body metabolizes alcohol

In the largest study of genetic factors linked to alcohol dependence, an international team of researchers identified a gene known to affect risk, and they determined that many other genes also contribute to risk for alcohol dependence to a lesser degree. In addition, the study linked genetic factors associated with alcohol dependence to other psychiatric disorders, such as depression, and […]

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Molecular mechanisms of an African folk medicine: Analysis of leaf extract reveals novel chemistry for therapeutic ion channel activation

Researchers in the Department of Physiology & Biophysics at the University of California, Irvine School of Medicine have discovered the molecular basis for therapeutic actions of an African folk medicine used to treat a variety of illnesses and disorders including diabetes, pain, headaches, paralysis and epilepsy. The herbal medicine, a leaf extract from the shrub Mallotus oppositifolius, has been used […]

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