Short-term use of opioids increases subjective pleasure: Risk of addiction

The human opioid system contributes to the regulation of emotions, pleasure and pain. Opioids are strong analgesics. In addition to effectively relieving pain, external opioids may improve mood and reduce negative emotions. However, not much has been known about the effect of opioids on emotional responses caused by external stimuli. Together with their colleagues from Aalto University and the University […]

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Probiotic-derived molecule may suppress fatal brain inflammation, preclinical study finds: Scientists explore how swallowing a ‘bacterial envelope molecule’ may prime your body to fend off viral infections

The existence of certain microorganisms in your gut may bolster the immune system’s ability to fend off a herpes viral attack that can cause fatal brain inflammation, reports a new City of Hope-led study. Researchers say the findings are the first to suggest that an envelope molecule from a bacterium called Bacteroides fragilis (B. fragilis) might be useful against viral […]

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How big data can be used for personal health

Scientists at the Stanford University School of Medicine and their collaborators followed a cohort of more than 100 people over several years, tracking the biology of what makes them them. Now, after collecting extensive data on the group’s genetic and molecular makeup, the researchers are piecing together a new understanding of what it means to be healthy and how deviations […]

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Alzheimer’s disease is a ‘double-prion disorder’: Self-propagating amyloid and tau prions found in post-mortem brain samples, with highest levels in patients who died young

Two proteins central to the pathology of Alzheimer’s disease act as prions — misshapen proteins that spread through tissue like an infection by forcing normal proteins to adopt the same misfolded shape — according to new UC San Francisco research. Using novel laboratory tests, the researchers were able to detect and measure specific, self-propagating prion forms of the proteins amyloid […]

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Technology automatically senses how Parkinson’s patients respond to medication: Novel approach doesn’t require patient or physician engagement

Parkinson’s disease (PD) is a chronic, progressive neurological disorder affecting approximately 6 million people globally and is expected to double by 2040. PD leads to disabling motor features including tremor, reduced speed, and gait/balance impairment leading to falls, as well as non-motor symptoms such as cognitive impairment and sleep and speech disorders. One of the most prevalent complications in PD […]

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Experiments with roundworms suggest alternatives for the treatment of schizophrenia: Researchers used C. elegans as an animal model to investigate the importance of certain human genes for the treatment of schizophrenia.

A group of Brazilian scientists have long conducted experiments with roundworms to investigate the role of schizophrenia-linked genes in patients’ response to antipsychotic drugs. The results obtained thus far point to new ways of understanding resistance to certain classes of medication. The studies are conducted by researchers in the Pharmacology Department of the Federal University of São Paulo’s Medical School […]

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Bioengineers create ultrasmall, light-activated electrode for neural stimulation

Neural stimulation is a developing technology that has beneficial therapeutic effects in neurological disorders, such as Parkinson’s disease. While many advancements have been made, the implanted devices deteriorate over time and cause scarring in neural tissue. In a recently published paper, the University of Pittsburgh’s Takashi D. Y. Kozai detailed a less invasive method of stimulation that would use an […]

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A new hope in treating neurodegenerative disease

Alzheimer’s disease (AD) is the most representative degenerative brain disease, accounting for 60 to 80% of all dementia cases. In search for new mechanism for AD, the research team led by Professor Seong-Woon Yu of Brain and Cognitive Sciences paid attention to the autophagy of microglia, brain immune cells, is suppressed by inflammation. ‘Microglia’ are phagocytic immune cells which are […]

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Fear and anger had different effects on conservatives and liberals, study suggests

Fear and anger related to the 2016 presidential election and climate change, one of the campaign’s major issues, had different effects on the way conservatives and liberals processed information about the two topics, according to the results of a study by a University at Buffalo communication researcher. The findings, published in the journal Journalism & Mass Communication Quarterly, suggest that […]

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Long-term trauma outcomes heavily impacted by gender and education level

Trauma is a leading cause of disability in the world, resulting in more disability-adjusted life years than any other disease. While in-hospital, trauma-related mortality has decreased to just 4 percent in the U.S., little is known about what happens to the 96 percent of patients who survive their trauma injuries but may suffer debilitating long-term effects. Through the Functional Outcomes […]

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