New yardstick offers diagnostic and treatment guidance for idiopathic anaphylaxis: Guidelines on next steps when there is no clear cause of severe reactions

Many people in danger of the severe allergic reaction known as anaphylaxis understand exactly what they need to avoid to stay safe. For some it’s an allergy to food, for others it can be insect stings, medications, hormones or even physical factors like exercise. But according to the new “Idiopathic Anaphylaxis Yardstick,” there are people for whom diagnosis and treatment […]

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Kidney disease: Senescent cell burden is reduced in humans by senolytic drugs

In a small safety and feasibility clinical trial, Mayo Clinic researchers have demonstrated for the first time that senescent cells can be removed from the body using drugs termed “senolytics.” The result was verified not only in analysis of blood but also in changes in skin and fat tissue senescent cell abundance. The findings appear in the journal EBioMedicine. This […]

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Simple model captures almost 100 years of measles dynamics in London: Disease dynamics are well predicted despite major disruptions caused by historical events

A simple epidemiological model accurately captures long-term measles transmission dynamics in London, including major perturbations triggered by historical events. Alexander Becker of Princeton University in New Jersey, U.S., and colleagues present these findings in PLOS Computational Biology. Previous studies have extensively explored how disease outbreaks are affected by variations in demography, such as birth rate, and variations in person-to-person contact, […]

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Why HIV patients are more likely to develop tuberculosis: Discovery could lead to new added therapy for HIV patients

Tuberculosis and HIV — two of the world’s deadliest infectious diseases — are far worse when they occur together. Now, Texas Biomedical Research Institute researchers have pinpointed an important mechanism at work in this troubling health problem. And, their discovery could lead to a new mode of treatment for people at risk. The results were published in the Journal of […]

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Scientists discover new breakthrough in cancer hair-loss treatment

Scientists have determined a new way to protect the hair follicle from chemotherapy in an effort to prevent hair loss as a result of cancer treatments. Researchers based at The University of Manchester have discovered a new strategy for how to protect hair follicles from chemotherapy, which could lead to new treatments that prevent chemotherapy-induced hair loss — arguably one […]

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Promising treatment for an incurable, deadly kidney disease

A potential treatment for polycystic kidney disease — a genetic disorder that causes the kidneys to swell with multiple cysts and can eventually lead to organ failure — has shown promising results in animal testing. A study describing the drug’s development and testing appears today in Nature Communications. The study shows an approximately 50 percent reduction in kidney size in […]

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Genetic discovery linked to rare eye disease

John A. Moran Eye Center physician-researcher Paul S. Bernstein, MD, PhD, and his patients at the University of Utah played a key role in the recent discovery of the first genetic cause for a rare eye disease. Macular telangiectasia type 2 (MacTel) affects about one in 5,000 people, causing a gradual loss of central vision, typically after age 40. As […]

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Patients taking nivolumab experience five-fold increase in overall survival compared to chemotherapy: Five-year outcomes from the randomized, phase 3 trials checkmate 017/057: nivolumab vs. docetaxel in previously treated NSCLC

Pooled data on two clinical trials demonstrate patients taking nivolumab realized a greater than five-fold increase in five-year overall survival rate compared with the chemotherapy docetaxel. The presentation was made today by Dr. Scott Gettinger of Yale Comprehensive Cancer Center, New Haven, Conn., at the IASLC 2019 World Conference on Lung Cancer, hosted by the International Association for the Study […]

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Survey shows many primary care doctors are unprepared to help patients avoid diabetes

Which of these is not a risk factor for prediabetes? A) Overweight B) Age 45 or older C) Being white D) Exercise less than three times per week The correct response is C — the actual risk factor being African American, Latino, Native American or Asian American. If you didn’t get it right, don’t feel badly. Chances are your doctor […]

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Measuring changes in magnetic order to find ways to transcend conventional electronics

Researchers around the world are constantly looking for ways to enhance or transcend the capabilities of electronic devices, which seem to be reaching their theoretical limits. Undoubtedly, one of the most important advantages of electronic technology is its speed, which, albeit high, can still be surpassed by orders of magnitude through other approaches that are not yet commercially available. A […]

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