Certain cells secrete a substance in the brain that protects neurons: Finding helps explain cascade of events leading to neurodegeneration

USC researchers have discovered a secret sauce in the brain’s vascular system that preserves the neurons needed to keep dementia and other diseases at bay. The finding, in a mouse model of the human brain, focuses on specific cells called pericytes and reveals that they play a previously unknown role in brain health. Pericytes secrete a substance that keeps neurons […]

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Mutant bacterial receptor could point to new therapies against opportunistic pathogen

Researchers have developed a new mutant version of a receptor used by a bacterial pathogen for a chemical communication process called quorum sensing, according to a study published June 13 in the open-access journal PLOS Pathogens by Bonnie Bassler of Princeton University, and colleagues. As the authors note, the mutant receptor could be used to identify therapeutic compounds that inhibit […]

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Body composition shown to affect energy spent standing versus sitting: Findings support increased standing time as a simple way to boost energy expenditure

A person’s body composition could influence the difference between the amount of energy they spend while sitting versus standing, according to new research published in the open-access journal PLOS ONE. Conducted by Francisco J. Amaro-Gahete of the University of Granada, Spain, and colleagues, this work adds to mounting evidence that more energy is expended while standing than while sitting or […]

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Veteran-directed care program is effective: Study suggests popular program that gives veterans flexible budgets for at-home caregivers should be expanded nationwide

A new study led by Boston University School of Public Health (BUSPH) and Veterans Affairs Boston Healthcare System researchers finds that a program that gives veterans flexible budgets for at-home caregivers is at least as effective as other veteran purchased-care services. Published in the June issue of Health Affairs, the study shows that, although the average enrollee in the Veterans […]

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Physical activity in preschool years can affect future heart health

Physical activity in early childhood may have an impact on cardiovascular health later in life, according to new research from McMaster University, where scientists followed the activity levels of hundreds of preschoolers over a period of years. They found that physical activity in children as young as three years old benefits blood vessel health, cardiovascular fitness and is key to […]

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A treasure map to understanding the epigenetic causes of disease

More than 15 years after scientists first mapped the human genome, most diseases still cannot be predicted based on one’s genes, leading researchers to explore epigenetic causes of disease. But the study of epigenetics cannot be approached the same way as genetics, so progress has been slow. Now, researchers at the USDA/ARS Children’s Nutrition Research Center at Baylor College of […]

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Immunotherapy drug found safe in treating cancer patients with HIV, study suggests: Researchers seek to break down HIV exclusions in cancer clinical trials

The results of a study led by physicians at Fred Hutchinson Cancer Research Center showed that patients living with HIV and one of a variety of potentially deadly cancers could be safely treated with the immunotherapy drug pembrolizumab, also known by its brand name, KEYTRUDA®. During an ASCO presentation concurrent with release of a study in JAMA Oncology, Fred Hutch […]

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New compounds could be used to treat autoimmune disorders

The immune system is programmed to rid the body of biological bad guys — like viruses and dangerous bacteria — but its precision isn’t guaranteed. In the tens of millions of Americans suffering from autoimmune diseases, the system mistakes normal cells for malicious invaders, prompting the body to engage in self-destructive behavior. This diverse class of conditions, which includes Type […]

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A gut check for heart failure patients

Heart failure patients who consume more dietary fibre tend to have healthier gut bacteria, which is associated with reduced risk of death or need of a heart transplant. The fibre study was presented today at Heart Failure 2019, a scientific congress of the European Society of Cardiology (ESC). “Our gut microbiota is composed of trillions of microorganisms that have the […]

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Home-schoolers see no added health risks over time: Better sleep, diet habits help counter shortfalls in formal exercise

Years of home-schooling don’t appear to influence the general health of children, according to a Rice University study. A report by Rice kinesiology lecturer Laura Kabiri and colleagues in the Oxford University Press journal Health Promotion International puts forth evidence that the amount of time a student spends in home school is “weakly or not at all related to multiple […]

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