Micro-control of liver metabolism

Researchers at TIFR have discovered molecular anticipation of feeding in the liver that is essential to ensure that the body, after fasting, adapts to utilize incoming nutrients upon re-feeding. Their findings, published in the international journal Cell Reports, show that very small RNA molecules called microRNAs control major metabolic pathways by inhibiting synthesis of proteins, and thus contribute to maintenance […]

Read more

New target for chronic pain: Shape of structure that nerve cells use to sense cold

People are great at detecting cold temperatures and also the cool sensation induced by natural substances like menthol, which is common in remedies used to soothe aching muscles. But it hasn’t been entirely clear how we do this. About a year ago, a group of researchers led by Seok-Yong Lee, Associate Professor of Biochemistry in the Duke University School of […]

Read more

Malignant bone marrow disease: New hope for MPN patients: Myeloproliferative neoplasms (MPNs) — a group of rare but malignant bone marrow disorders

MPNs are a group of rare, malignant diseases of the bone marrow involving the production of an excess of red blood cells, white blood cells and/or platelets. MPNs are chronic diseases with only 1 to 2 new cases diagnosed per 100,000 people every year. MPNs can affect people at any age, but they are most common among adults around 60 […]

Read more

Method to ‘turn off’ mutated melanoma: New study provides novel insights into the pathogenesis and treatment of NRAS mutant melanoma

Melanoma is the deadliest form of skin cancer and notorious for its resistance to conventional chemotherapy. Approximately 25 percent of melanoma is driven by oncogenic mutations in the NRAS gene, making it a very attractive therapeutic target. However, despite decades of research, no effective therapies targeting NRAS have been forthcoming. For the first time, an international group of researchers has […]

Read more

Americans concerned about weight, but don’t understand link to heart conditions, health

A Cleveland Clinic survey finds that while most Americans (88 percent) understand that there is a connection between a healthy heart and a healthy weight, most aren’t doing enough — or anything — to combat their own weight issues. The survey found 74 percent are concerned about their weight and 65 percent are worried about getting heart disease due to […]

Read more

Short bouts of stairclimbing throughout the day can boost health

It just got harder to avoid exercise. A few minutes of stair climbing, at short intervals throughout the day, can improve cardiovascular health, according to new research from kinesiologists at McMaster University and UBC Okanagan. The findings, published in the journal Applied Physiology, Nutrition and Metabolism, suggest that virtually anyone can improve their fitness, anywhere, any time. “The findings make […]

Read more

Hand-knitted molecules: Chemistry at very small scales

The fabrication of electronic components usually follows a top-down pathway in specialized physical laboratories. Using special carving tools in clean rooms, scientists are capable of fabricating structures reaching only a few nanometers. However, atomic precision remains very challenging and usually requires special microscopes such as an Atomic Force Microscope (AFM) or a Scanning Tunneling Microscope (STM). Chemists on the other […]

Read more

Mechanism for leukaemia cell growth revealed, prompting new treatment hopes: Research reveals new blood cell mechanism which drives leukaemia growth

A mechanism which drives leukemia cell growth has been discovered by researchers at the University of Sussex, who believe their findings could help to inform new strategies when it comes to treating the cancer. Acute myeloid leukemia (AML) is a devastating blood cancer with around 3,000 new cases annually in the UK. Despite considerable improvement in patient survival over the […]

Read more

Personalized treatment benefits kidney cancer patients

 Personalized treatment plans may extend life expectancy for early-stage kidney cancer patients who have risk factors for worsening kidney disease, according to a new study published in the journal Radiology. Kidney, or renal, tumors are often discovered at an early stage and are frequently treated with partial nephrectomy, a surgical procedure in which the tumor and part of the kidney […]

Read more

Health effects of metabolic ‘magic bullet’ protein: New model lets scientists activate health-promoting enzyme AMPK at any time and in any tissue

The metabolic protein AMPK has been described as a kind of magic bullet for health. Studies in animal models have shown that compounds that activate the protein have health-promoting effects to reverse diabetes, improve cardiovascular health, treat mitochondrial disease — even extend life span. However, how much of the effects of these compounds can be fully attributed to AMPK versus […]

Read more
1 2 3