Many patients with iNPH develop Alzheimer’s disease, too

Up to one in five patients treated for idiopathic normal pressure hydrocephalus, iNPH, also develop Alzheimer’s disease, according to a new study from the University of Eastern Finland and Kuopio University Hospital. The researchers were able to predict the development of Alzheimer’s disease by using the Disease State Index, DSI, that combines patient-specific data from various sources. The results were […]

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Celiac disease screening for family members

Celiac disease is an immune reaction to eating gluten. A recent Mayo Clinic study found that this autoimmune disease tends to run in families. Researchers say screening family members of celiac disease patients could prevent long-term complications, such as nutritional deficiencies, development of new autoimmune conditions and small bowel malignancy. If one member of a family has celiac disease, there […]

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More hospital days seen with antipsychotic use in Alzheimer disease

(HealthDay)—Alzheimer disease patients who initiate treatment with antipsychotic medications spend more days hospitalized than those who do not initiate antipsychotics, according to a study recently published in the Journal of Post-Acute and Long-Term Care Medicine. Marjaana Koponen, Ph.D., of the Kuopio Research Center of Geriatric Care at the University of Eastern Finland, and colleagues used a nationwide exposure-matched cohort to […]

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Study shows biomarker accurately diagnoses deadly infant disease

A diagnostic study of 136 premature infants found that a protein involved in managing harmful bacteria in the human intestine is a reliable biomarker for the noninvasive detection of necrotizing enterocolitis (NEC). Led by researchers and clinicians at LSU Health New Orleans School of Medicine, this is one of the largest prospective clinical studies in premature infants yet. Results of […]

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Researchers develop noninvasive method to detect early-stage liver disease

A safer and more sensitive contrast dye for MRI tests developed by a team led by Georgia State University researchers may provide the first effective, noninvasive method for detecting and diagnosing early-stage liver diseases, including liver fibrosis. “It’s a revolutionary change for the field as the first robust detection of the early stage of liver fibrosis,” said Jenny Yang, a […]

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Cell family trees tracked to discover their role in tissue scarring and liver disease

Researchers have discovered that a key cell type involved in liver injury and cancer consists of two cellular families with different origins and functions. The research by academics from the Universities of Edinburgh and Bristol and funded by the Wellcome Trust and Medical Research Council, is published today [Tuesday 15 October] in Nature Communications. The distinguishing feature of these families—whether […]

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Researchers create new viral vector for improved gene therapy in sickle cell disease

Researchers at the National Institutes of Health have developed a new and improved viral vector—a virus-based vehicle that delivers therapeutic genes—for use in gene therapy for sickle cell disease. In advanced lab tests using animal models, the new vector was up to 10 times more efficient at incorporating corrective genes into bone marrow stem cells than the conventional vectors currently […]

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'I had to have chemotherapy after catching a flesh-eating disease in the Amazon'

Phillippa Stewart took on the challenge of a lifetime when she began a three month, world-first kayaking journey down an Amazonian river. But things took a turn for the worse when she contracted a deadly, flesh-eating parasite along the way. Now, Philippa wants to raise awareness about leishmaniasis and the fact 1 billion of the world’s poorest people are at […]

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First systematic review and meta-analysis suggests AI may be as effective as health professionals at diagnosing disease

Artificial intelligence (AI) appears to detect diseases from medical imaging with similar levels of accuracy as health-care professionals, according to the first systematic review and meta-analysis, synthesising all the available evidence from the scientific literature published in The Lancet Digital Health journal. Nevertheless, only a few studies were of sufficient quality to be included in the analysis, and the authors […]

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Gum disease linked with higher risk of hypertension

People with gum disease (periodontitis) have a greater likelihood of high blood pressure (hypertension), according to a study published today in Cardiovascular Research, a journal of the European Society of Cardiology (ESC). Senior author Professor Francesco D’Aiuto of UCL Eastman Dental Institute, UK, said: “We observed a linear association—the more severe periodontitis is, the higher the probability of hypertension. The […]

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