New discovery on the activity and function of MAIT cells during acute HIV infection

In a new study published in Nature Communications, researchers at Karolinska Institutet show that mucosa-associated invariant T cells (MAIT cells) of the human immune system respond with dynamic activity and reprogramming of gene expression during the initial phase of HIV infection. The study fills a knowledge gap, as previously, the function of MAIT cells during this particular phase was not […]

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Machine learning’s next frontier: Epigenetic drug discovery

Machine learning’s powerful ability to detect patterns in complex data is revolutionizing how we drive, how we diagnose disease and now, how we discover new drugs. Scientists at Sanford Burnham Prebys Medical Discovery Institute have developed a machine-learning algorithm that gleans information from microscope images—allowing for high-throughput epigenetic drug screens that could unlock new treatments for cancer, heart disease, mental […]

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Discovery of mechanism behind precision cancer drug opens door for more targeted treatment

New research that uncovers the mechanism behind the newest generation of cancer drugs is opening the door for better targeted therapy. PARP inhibitors are molecular targeted cancer drugs used to treat women with ovarian cancer who have the BRCA1 and BRCA2 gene mutations. The drugs are showing promise in late-stage clinical trials for breast cancer, prostate cancer and pancreatic cancer […]

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The cell discovery that could stop allergies

A new cell type that could stop allergies before they begin has been discovered by researchers at the Australian National University (ANU). The finding gives hope to people who live with a range of allergic conditions including asthma, eczema and life-threatening anaphylaxis. “By carefully studying the tonsils of children undergoing routine tonsillectomies, we identified a new cell type of the […]

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New discovery in how mammals sense the cold could lead to new pain relief drugs

Researchers at UCL have shown for the first time that mammals detect different intensities of cold using distinct sensory neuron systems, a finding which could lead to the development of new drugs to treat cold pain. The study on mice, published in Proceedings of the National Academy of Sciences, set out to understand more about the two known sensory neuron […]

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A new model for heart valve disease drug discovery

An article published in Experimental Biology and Medicine describes a new model for heart valve physiology. The study, led by Dr. Carla Lacerda, from the Department of Chemical Engineering at Texas Tech University reports that 10% cyclic radial strain on isolated mitral valve anterior leaflets provides a true physiological environment that can be used for mechanistic studies and drug discovery. […]

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