New method described for quantifying antisense oligonucleotides in nuclei

A novel method uses subcellular fractionation to quantify label-free antisense oligonucleotides (AONs)- designed to silence targeted genes—that have crossed into the nucleus of a cell, where they can exert their effects. Researchers used this method to correlate nuclear entry of several AON molecules with target gene knockdown and they report their results in Nucleic Acid Therapeutics. Troels Koch and colleagues […]

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Molecular control of neurotransmitter linked to autism described

Many neurodevelopmental disorders such as epilepsy, schizophrenia, and autism have been linked to disruption of the key neurotransmitter GABA, but the underlying causes of the disruptions have been difficult to pinpoint. In two new papers published Oct. 15 in Science Signaling, researchers from Yale, France, Japan, and the United Kingdom have zeroed in on a molecular mechanism crucial to normal […]

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Chronic kidney disease of undetermined causes described originally in Central America and Sri Lanka

Chronic kidney disease of undetermined causes (CKDu), initially reported among agricultural communities in Central America and Sri Lanka, is also present in India, particularly in Southern rural areas, and could be common in other tropical and subtropical rural settings. These are the main conclusions of a new study published in BMJ Open. CDKu is considered an epidemic in Central America […]

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