New drug mimics benefits of ketamine for depression

A new small-molecule drug produced a rapid antidepressant response similar to that of ketamine when tested in mice, a new Yale-led study published April 16 in the Journal of Clinical Investigation shows. The effects of the drug, called NV-5138, in rodent models mimicked the rapid actions of the anesthetic ketamine, a variation of which, Esketamine, was recently approved by the […]

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CBT can provide better long-term relief for IBS symptoms

Irritable Bowel Syndrome (IBS) is a common gastrointestinal disorder affecting 10 — 20 per cent of people. Abdominal pain, bloating and altered bowel habit significantly affect patients’ quality of life and can force them to take days off work. New research has shown that Cognitive Behavioural Therapy (CBT) tailored specifically for IBS and delivered over the telephone or through an […]

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Ketamine reverses neural changes underlying depression-related behaviors in mice: Study sheds light on the neural mechanisms underlying remission of depression

Researchers have identified ketamine-induced brain-related changes that are responsible for maintaining the remission of behaviors related to depression in mice — findings that may help researchers develop interventions that promote lasting remission of depression in humans. The study, funded by the National Institute of Mental Health (NIMH), part of the National Institutes of Health, appears in the journal Science. Major […]

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Psychiatry: Multigene test predicts depression risk

According to the World Health Organization, depression is now the leading cause of disability, globally affecting more than 300 million people worldwide. Depression is a condition that results from interactions between biological, psychological and social factors. Although depression can become manifest at any age, it often first emerges during adolescence. Identifying the risk factors for depression before clinically confounding symptoms […]

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David Walliams health: The BGT judge has battled with depression – what are the symptoms?

Perhaps best-known for his work on Little Britain, David Walliams, 47, has entertained British TV audiences for almost 20 years. As well as forging a career as a successful actor and comedian, Walliams is a well-established writer and a popular judge on Britain’s Got Talent. Despite his successes, the TV personality has battled with depression, which he has publicly opened […]

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Depression: gene test shows which children are at risk

Many children and young people Depression is detected, is often too late. Medical scientists have now succeeded for the first time on the basis of a genetic profile, the risk of serious disease predict. In Germany, more than half of the children and adolescents who suffer from Depression are not treated in a timely manner. An international team of researchers […]

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F.D.A. Approves First Drug for Postpartum Depression

The first drug for women suffering postpartum depression received federal approval on Tuesday, a move likely to pave the way for a wave of treatments to address a debilitating condition that is the most common complication of pregnancy. The drug works very quickly, within 48 hours — a significant improvement over currently available antidepressants, which can take two to four […]

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Doctors Welcome New Depression Drug, Cautiously

Doctors welcomed federal approval this week of a new, fast-acting nasal spray for depression. But also they expressed concerns about its cost and long-term effects, as well as the logistics of administering it in accordance with safety requirements. The new drug, esketamine, made by Janssen Pharmaceuticals, won approval from the Food and Drug Administration on Tuesday for people who have […]

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Deep brain stimulation sites for OCD target distinct symptoms: Two DBS sites equally reduced OCD symptoms but improved distinct symptoms

Deep brain stimulation (DBS) reduces symptoms of severe obsessive-compulsive disorder (OCD) during stimulation of either the ventral capsule (VC) or anteromedial subthalamic nucleus (amSTN), according to a study in Biological Psychiatry. DBS of the regions reduced OCD symptoms to a similar extent, but produced distinct effects on specific symptoms — VC stimulation drastically improved mood, whereas amSTN stimulation in the […]

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Fast-Acting Depression Drug, Newly Approved, Could Help Millions

Of the 16 million American adults who live with depression, as many as one-quarter gain little or no benefit from available treatments, whether drugs or talk therapy. They represent perhaps the greatest unmet need in psychiatry. On Tuesday, the Food and Drug Administration approved a prescription treatment intended to help them, a fast-acting drug derived from an old and widely […]

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