Researchers create new viral vector for improved gene therapy in sickle cell disease

Researchers at the National Institutes of Health have developed a new and improved viral vector—a virus-based vehicle that delivers therapeutic genes—for use in gene therapy for sickle cell disease. In advanced lab tests using animal models, the new vector was up to 10 times more efficient at incorporating corrective genes into bone marrow stem cells than the conventional vectors currently […]

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One-fifth of US surgeons still overusing riskier procedure to create kidney dialysis access

Long-term hemodialysis is a lifesaver for approximately half a million patients in the United States with kidney failure (also known as end-stage renal disease, or ESRD) who are either waiting on or unsuitable for a kidney transplant. But before the external machinery can take over the function of the kidneys—filtering and cleansing wastes from the blood—a minor surgical procedure is […]

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Drug-resistant cancer cells create own Achilles heel

The cells of most patients’ cancers are resistant to a class of drugs, called proteasome inhibitors, that should kill them. When studied in the lab, these drugs are highly effective, yet hundreds of clinical trials testing proteasome inhibitors have failed. Now scientists may have solved the mystery of these cells’ surprising hardiness. The key: Resistant cancer cells have shifted how […]

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Researchers create a better way to transport life-saving vaccines

Researchers at McMaster University have invented a stable, affordable way to store fragile vaccines for weeks at a time at temperatures up to 40C, opening the way for life-saving anti-viral vaccines to reach remote and impoverished regions of the world. The new method combines the active ingredients in existing vaccines with a sugary gel, where they remain viable for eight […]

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Here’s how cancer hijacks wound healing to create its own blood supply

Researchers at the University of Virginia School of Medicine have shed light on how cancers hijack the body’s natural wound-healing response to grow and spread. The researchers have identified specific processes within endothelial cells – the cells that line blood vessels – that tumors use to build out their own blood supply. These processes are normally used by the body […]

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