Gene involved in colorectal cancer also causes breast cancer

Rare mutations in the NTHL1 gene, previously associated with colorectal cancer, also cause breast cancer and other types of cancer. Researchers from Radboud university medical center, Leiden University Medical Center and the Princess Máxima Center in the Netherlands report this new multi-tumor syndrome, in collaboration with international colleagues, in Cancer Cell. Nicoline Hoogerbrugge, professor of Hereditary Cancer at Radboud university […]

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Loss of two genes drives a deadly form of colorectal cancer, reveals a potential treatment

Colorectal cancers arise from earlier growths, called polyps, found on the inner surface of the colon. Scientists are now learning that polyps use two distinct molecular pathways as they progress to cancer, called the “conventional” and “alternative” pathways. The latter leads to an often treatment-resistant tumor, called serrated colorectal cancer; thus, distinguishing between these two cancer types holds implications for […]

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