Potential treatment target for Crohn’s disease

There is no cure for the more than 1.6 million people in the United States living with Crohn’s disease (CD) and its symptoms, including abdominal pain, intestinal distress and severe weight-loss. CD is a form of inflammatory bowel disease (IBD) in which the body’s own immune system attacks the gastrointestinal tract, and treatment is focused on controlling the symptoms of […]

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Newly developed approach shows promise in silencing HIV infection

Researchers from The University of Texas Medical Branch at Galveston have discovered a new potential medication that works with an HIV-infected person’s own body to further suppress the ever present but silent virus that available HIV treatments are unable to combat. Although the potential new drug could complement the current HIV anti-retroviral therapy (ART) medications, it may also be possible […]

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Smart brain stimulators: Next-gen Parkinson’s disease therapy

Researchers at the University of Houston have found neuro biomarkers for Parkinson’s disease that can help create the next generation of “smart” deep brain stimulators, able to respond to specific needs of Parkinson’s disease patients. Those with the disease often undergo the high-frequency brain stimulation, a well-established therapy for the progressive nervous system disorder that affects movement, but the therapy […]

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Body and mind need care in mental illness

The 18-year life expectancy gap between people with mental illness and the general population can only be bridged by protecting patients’ physical and mental health, according to a new study. As part of a Lancet Psychiatry Commission into mental illness, University of Queensland researchers found patients’ physical health was often overlooked in pursuit of treating the mind. UQ psychiatrist Associate […]

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Body composition shown to affect energy spent standing versus sitting: Findings support increased standing time as a simple way to boost energy expenditure

A person’s body composition could influence the difference between the amount of energy they spend while sitting versus standing, according to new research published in the open-access journal PLOS ONE. Conducted by Francisco J. Amaro-Gahete of the University of Granada, Spain, and colleagues, this work adds to mounting evidence that more energy is expended while standing than while sitting or […]

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Veteran-directed care program is effective: Study suggests popular program that gives veterans flexible budgets for at-home caregivers should be expanded nationwide

A new study led by Boston University School of Public Health (BUSPH) and Veterans Affairs Boston Healthcare System researchers finds that a program that gives veterans flexible budgets for at-home caregivers is at least as effective as other veteran purchased-care services. Published in the June issue of Health Affairs, the study shows that, although the average enrollee in the Veterans […]

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Physical activity in preschool years can affect future heart health

Physical activity in early childhood may have an impact on cardiovascular health later in life, according to new research from McMaster University, where scientists followed the activity levels of hundreds of preschoolers over a period of years. They found that physical activity in children as young as three years old benefits blood vessel health, cardiovascular fitness and is key to […]

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Short-term use of opioids increases subjective pleasure: Risk of addiction

The human opioid system contributes to the regulation of emotions, pleasure and pain. Opioids are strong analgesics. In addition to effectively relieving pain, external opioids may improve mood and reduce negative emotions. However, not much has been known about the effect of opioids on emotional responses caused by external stimuli. Together with their colleagues from Aalto University and the University […]

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Defects in heart valve cilia during fetal development cause mitral valve prolapse

Genetic variation in heart valve cells of the developing fetus create the blueprint for the later development of mitral valve prolapse, according to the cover story of today’s Science Translational Medicine. The mutations cause defects in antenna-like cellular structures called primary cilia that previously had no known function in the heart valves. These findings were made possible by an international […]

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Tracking symptoms: New tool helps providers identify underlying causes: SymTrak advances clinicians toward next generation of population health management

An easy to use, brief, inexpensive new tool developed and validated by researchers at the Regenstrief Institute and Indiana University will help healthcare providers track and potentially identify early onset of more complex, serious underlying issues that could otherwise go undetected. The tool tracks symptoms such as pain, fatigue, sleep disturbance, memory problems, anxiety and depression in older adults enabling […]

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