Kidney disease: Senescent cell burden is reduced in humans by senolytic drugs

In a small safety and feasibility clinical trial, Mayo Clinic researchers have demonstrated for the first time that senescent cells can be removed from the body using drugs termed “senolytics.” The result was verified not only in analysis of blood but also in changes in skin and fat tissue senescent cell abundance. The findings appear in the journal EBioMedicine. This […]

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Simple model captures almost 100 years of measles dynamics in London: Disease dynamics are well predicted despite major disruptions caused by historical events

A simple epidemiological model accurately captures long-term measles transmission dynamics in London, including major perturbations triggered by historical events. Alexander Becker of Princeton University in New Jersey, U.S., and colleagues present these findings in PLOS Computational Biology. Previous studies have extensively explored how disease outbreaks are affected by variations in demography, such as birth rate, and variations in person-to-person contact, […]

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Why HIV patients are more likely to develop tuberculosis: Discovery could lead to new added therapy for HIV patients

Tuberculosis and HIV — two of the world’s deadliest infectious diseases — are far worse when they occur together. Now, Texas Biomedical Research Institute researchers have pinpointed an important mechanism at work in this troubling health problem. And, their discovery could lead to a new mode of treatment for people at risk. The results were published in the Journal of […]

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Promising treatment for an incurable, deadly kidney disease

A potential treatment for polycystic kidney disease — a genetic disorder that causes the kidneys to swell with multiple cysts and can eventually lead to organ failure — has shown promising results in animal testing. A study describing the drug’s development and testing appears today in Nature Communications. The study shows an approximately 50 percent reduction in kidney size in […]

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Caregiver stress: The crucial, often unrecognized byproduct of chronic disease

There is growing evidence that caregivers of patients with cardiovascular disease (CVD) are vulnerable to developing their own poor cardiovascular health. Investigators report in the Canadian Journal of Cardiology, published by Elsevier, on a proof-of-concept couples-based intervention in a cardiac rehabilitation setting. This intervention has shown potential for reducing caregiver distress, and future studies are evaluating its impact on both […]

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What drives inflammation in type 2 diabetes? Not glucose, says new research

To date, the underlying causes of inflammation in obesity and type 2 diabetes mellitus (T2DM) have been poorly understood, which has hampered efforts to develop treatments to prevent complications from a disease that is the third leading cause of death in the United States. But new research at the University of Kentucky shows that changes to mitochondria — the powerhouse […]

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Potential treatment target for Crohn’s disease

There is no cure for the more than 1.6 million people in the United States living with Crohn’s disease (CD) and its symptoms, including abdominal pain, intestinal distress and severe weight-loss. CD is a form of inflammatory bowel disease (IBD) in which the body’s own immune system attacks the gastrointestinal tract, and treatment is focused on controlling the symptoms of […]

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Newly developed approach shows promise in silencing HIV infection

Researchers from The University of Texas Medical Branch at Galveston have discovered a new potential medication that works with an HIV-infected person’s own body to further suppress the ever present but silent virus that available HIV treatments are unable to combat. Although the potential new drug could complement the current HIV anti-retroviral therapy (ART) medications, it may also be possible […]

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Smart brain stimulators: Next-gen Parkinson’s disease therapy

Researchers at the University of Houston have found neuro biomarkers for Parkinson’s disease that can help create the next generation of “smart” deep brain stimulators, able to respond to specific needs of Parkinson’s disease patients. Those with the disease often undergo the high-frequency brain stimulation, a well-established therapy for the progressive nervous system disorder that affects movement, but the therapy […]

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Body and mind need care in mental illness

The 18-year life expectancy gap between people with mental illness and the general population can only be bridged by protecting patients’ physical and mental health, according to a new study. As part of a Lancet Psychiatry Commission into mental illness, University of Queensland researchers found patients’ physical health was often overlooked in pursuit of treating the mind. UQ psychiatrist Associate […]

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