Protein ‘spat out’ by cancer cells promotes tumor growth

Prostate cancer cells change the behaviour of other cells around them, including normal cells, by ‘spitting out’ a protein from their nucleus, new research has found. The tiny pieces of protein are taken up by the other cells, provoking changes that promote tumour growth and—the researchers believe—help the cancer hide from the body’s immune system. The process has been captured […]

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Vitamin B3 analogue boosts production of blood cells

Stem cell-based therapies are becoming increasingly common, especially in the treatment of blood cancers like lymphoma and leukemia. In these cases, the patient’s cancerous blood stem cells are removed and replaced with new, healthy ones. However, up to a quarter of cases end in death because replenishing of blood cells is too slow. One solution to this is to boost […]

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Reducing B cells with CAR T cells is effective treatment of experimental lupus

Depleting the number of harmful B cells with a novel immunotherapy that employs modified T cells may offer an effective strategy to treat lupus, according to a new study funded by the Lupus Research Alliance. These findings offer a renewed optimism for the elimination of B cells to provide a therapeutic option in lupus and pave the way for clinical […]

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Researchers discover the brain cells that make pain unpleasant

If you step on a tack, neurons in your brain will register two things: that there’s a piercing physical sensation in your foot, and that it’s not pleasant. Now, a team of scientists at Stanford University has identified a bundle of brain cells in mice responsible for the latter—that is, the negative emotions of pain. Pain research has traditionally focused […]

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Scientists generate high-quality human vascular cells through genome editing technology

Scientists from the Institute of Biophysics of the Chinese Academy of Sciences (CAS), Peking University and the Institute of Zoology of CAS have generated the world’s first genetically enhanced human vascular cells by targeting a single longevity gene, FOXO3. The study was recently published in Cell Stem Cell. This six-year joint research effort represents the first time human vascular cell […]

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Muscle stem cells can drive cancer that arises in Duchenne muscular dystrophy

People with Duchenne muscular dystrophy (DMD) can develop an otherwise-rare muscle cancer, called rhabdomyosarcoma, due to the muscle cells’ continuous work to rebuild the damaged tissue. However, little is known about how the cancer arises, hindering development of a treatment or test that could predict cancer risk. Now, scientists from Sanford Burnham Prebys Medical Discovery Institute (SBP) have demonstrated that […]

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Research confirms nerve cells made from skin cells are a valid lab model for studying disease

The incidence of some neurological diseases—especially those related to aging, such as Alzheimer’s and Parkinson’s diseases—is increasing. To better understand these conditions and evaluate potential new treatments, researchers need accurate models that they can study in the lab. Researchers from the Salk Institute, along with collaborators at Stanford University and Baylor College of Medicine, have shown that cells from mice […]

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Study differentiates iPS cells into various ocular lineages

The discovery of pluripotent stem cells, which have the ability to differentiate into the huge range of different cell lineages that make up the human body, signaled the start of a new era in biological science and medicine. Although we are also now able to reprogram regular cells to exhibit this pluripotency, we still have much to learn about the […]

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The ‘wrong’ connective tissue cells signal worse prognosis for breast cancer patients

In certain forms of cancer, connective tissue forms around and within the tumour. One previously unproven theory is that there are several different types of connective tissue cells with different functions, which affect the development of the tumour in different ways. Now, a research team at Lund University in Sweden has identified three different types of connective tissue cells. In […]

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Brain, muscle cells found lurking in kidney organoids grown in lab

Scientists hoping to develop better treatments for kidney disease have turned their attention to growing clusters of kidney cells in the lab. One day, so-called organoids—grown from human stem cells—may help repair damaged kidneys in people or be used to test drugs developed to fight kidney disease. But new research from Washington University School of Medicine in St. Louis has […]

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