Researchers ID risks for second childhood cancers

Chemotherapy and radiation treatments have helped children survive cancer. Now University of Minnesota researchers are trying to find the ideal combinations that prevent the disease from coming back. Comparing outcomes for 22,000 survivors, the researchers found, as expected, that children treated with tumor-killing radiation were at elevated risks of second cancers. But they also discovered that certain chemo drugs increased […]

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Laboratory studies identify a potential way to treat human cancers with ARID1A mutations

A new study shows that tumor cells depleted of ARID1A—a protein that acts as a cancer suppressor—become highly sensitive to anticancer poly ADP ribose polymerase (PARP) inhibitor drugs after radiation treatment. The research, led by Johns Hopkins Kimmel Cancer Center researchers, could advance efforts to treat many human cancers with loss of ARID1A that are resistant to current standard treatments, […]

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Annual mammography screenings aren’t the best option for female survivors of some childhood cancers

Female survivors of childhood cancers who have been treated with thoracic radiation, such as survivors of Hodgkin’s lymphoma (HL), have a higher risk of developing breast cancer later in life compared to the general population. To mitigate this risk, current guidelines in Ontario recommend that female HL survivors undergo annual mammography and MRI screenings starting at age 30, the same […]

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Blood cancer’s Achilles’ heel opens door for new treatments

New findings about a fatal form of blood cancer could aid the development of new drugs with significantly less harmful side effects than existing chemotherapy. The discovery could lead to novel treatments that efficiently eliminate blood cancer cells in acute myeloid leukaemia (AML), without harming healthy blood cells. Researchers have discovered how a protein in the body plays a key […]

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Federal study gives new options for people with rare cancers

People with rare cancers have been out of luck—not only do most lack good treatments but drug companies also don’t pursue them because of small potential sales. Now, a federal study that pools these folks gives them strength in numbers and new options. The first results from this novel effort were revealed at an American Association for Cancer Research conference […]

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More proof high-fiber diets help prevent cancers, heart disease

(HealthDay)—A large, new analysis helps confirm that eating lots of grains, vegetables and fruit lowers your risk of dying early from cancer or heart disease. When compared with those who consume very little fiber, people at the high end of the fiber-eating spectrum saw their risk for dying from heart disease, stroke, type 2 diabetes and/or colon cancer plummet by […]

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Rare variants associated with interval breast cancers

(HealthDay)—Though common breast cancer variants indicate increased breast cancer risk, certain rare variants are associated with an increased risk for interval breast cancers and death, according to a study published in the Nov. 1 issue of Cancer Research. Jingmei Li, Ph.D., from the Genome Institute of Singapore, and colleagues assessed whether the genetic risk stratification of breast cancer by rare […]

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