Immunotherapy drug found safe in treating cancer patients with HIV, study suggests: Researchers seek to break down HIV exclusions in cancer clinical trials

The results of a study led by physicians at Fred Hutchinson Cancer Research Center showed that patients living with HIV and one of a variety of potentially deadly cancers could be safely treated with the immunotherapy drug pembrolizumab, also known by its brand name, KEYTRUDA®. During an ASCO presentation concurrent with release of a study in JAMA Oncology, Fred Hutch […]

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New blood test uses DNA ‘packaging’ patterns to detect multiple cancer types

Researchers at the Johns Hopkins Kimmel Cancer Center have developed a simple new blood test that can detect the presence of seven different types of cancer by spotting unique patterns in the fragmentation of DNA shed from cancer cells and circulating in the bloodstream. In a proof-of-concept study, the test, called DELFI (DNA evaluation of fragments for early interception), accurately […]

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The world sensation is not exists on the bubble: cancer test at the University hospital of Heidelberg

It was three months before the sensational (“image”) and milestone celebrated Bleeding to breast cancer, early diagnosis remains a scientific pipe dream. According to a report by the “süddeutsche Zeitung”, the from the University hospital of Heidelberg with a study commissioned tumor biologist Magnus von Knebel Doeberitz to the conclusion that there is not the much-publicized PR campaign promised process […]

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Giuliana Rancic Recalls How She Felt After Double Mastectomy: 'This Isn't Going to Define You'

TV host and entrepreneur Giuliana Rancic has been cancer free for almost a decade. But there was a time, says the 44-year-old mother of son Duke, when cancer was all she and her husband Bill could think about. “I am 7 years cancer free, which is wonderful, but I have to say that it’s interesting being 7 years out — […]

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A Rare Genetic Mutation Leads to Cancer. The Fix May Already Be in the Drugstore.

When Kelley Oliver Douglass got breast cancer, a genetic counselor posed an odd question: Do you and your children have trouble finding hats that fit? They did, and that gave the counselor a clue to the source of the cancer: a mutation in a gene called Pten. In addition to increasing head circumference, this rare mutation markedly raises the risk […]

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Conquering cancer’s infamous KRAS mutation

KRAS is one of the most challenging targets in cancer. Despite its discovery more than 60 years, researchers still struggle to inhibit its mutated form — earning its reputation as “undruggable.” Yet, the hunt for an Achilles’ heel continues, as cancers driven by KRAS mutations are both common and deadly. Now, scientists from Sanford Burnham Prebys and PHusis Therapeutics have […]

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Measuring chromosome imbalance could clarify cancer prognosis: A study of prostate cancer finds ‘aneuploid’ tumors are more likely to be lethal than tumors with normal chromosome numbers

Most human cells have 23 pairs of chromosomes. Any deviation from this number can be fatal for cells, and several genetic disorders, such as Down syndrome, are caused by abnormal numbers of chromosomes. For decades, biologists have also known that cancer cells often have too few or too many copies of some chromosomes, a state known as aneuploidy. In a […]

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Discovery of oral cancer biomarkers could save thousands of lives

Oral cancer is known for its high mortality rate in developing countries, but an international team of scientists hope its latest discovery will change that. Researchers from the University of Otago, New Zealand, and the Indian Statistical Institute (ISI), Kolkata, have discovered epigenetic markers that are distinctly different in oral cancer tissues compared to the adjacent healthy tissues in patients. […]

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Cancers ‘change spots’ to avoid immunotherapy

Cancers can make themselves harder for new immunotherapies to see by ‘changing their spots’ — and switching off a key molecule on the surface of cells that is otherwise recognised by treatment. Researchers found that they could test samples from patients with bowel cancer to identify which were most likely to respond to immunotherapy by assessing molecular changes within miniature […]

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Ovarian cancer patients undertested for mutations that could guide clinical care

Fewer than a quarter of breast cancer patients and a third of ovarian cancer patients diagnosed between 2013 and 2014 in two states underwent genetic testing for cancer-associated mutations, according to a study by researchers at the Stanford University School of Medicine and several other organizations. The findings indicate that substantial gaps exist between national guidelines for testing and actual […]

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