Stem cell researchers reactivate ‘back-up genes’ in the lab: Researchers in Belgium present new findings on X chromosome reactivation

Vincent Pasque and his team at KU Leuven have unravelled parts of a mechanism that may one day help to treat Rett syndrome and other genetic disorders linked to the X chromosome. Women and most female mammals have two X chromosomes, but only one of these is active in any given cell. This active X chromosome is selected through a […]

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Single protein plays important dual transport roles in the brain

Just as a packaging breakdown can hamstring delivery of cables, switches and connectors to a house under construction, removing a protein from neurons can block the “shipment” of proteins to developing axons. Axons are the telephone wires of the nervous system. They convey information to dendrites on other nerve cells, in a processing network of phenomenal complexity that is the […]

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Possible new treatment strategy for lung cancer: Combination therapy targeting KRAS mutation could provide benefit to nearly a third of lung cancer patients

Lung cancer is the second most common cancer found in both men and women. It is estimated there will be roughly 228,000 new lung cancer cases this year, and nearly 30% of those patients will have mutations in the KRAS pathway. This type of mutation makes the cancer more aggressive and difficult to treat. Researchers at Moffitt Cancer Center are […]

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Scientists reverse aging process in rat brain stem cells

New research, published today in Nature, reveals how increasing brain stiffness as we age causes brain stem cell dysfunction, and demonstrates new ways to reverse older stem cells to a younger, healthier state. The results have far reaching implications for how we understand the ageing process, and how we might develop much-needed treatments for age-related brain diseases. As our bodies […]

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Human cells assembling into fractal-like clusters

Tree-like branching structures are everywhere in the human body, from the bronchial system in the lungs to the spidering capillaries that supply blood to the extremities. Researchers have long worked to understand the cellular signaling needed to build these intricate structures, but new research suggests that simple physics may play an underappreciated role. The research, published in the Proceedings of […]

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Better tools, better cancer immunotherapy

In the journal Science Immunology, researchers from DTU Health Technology and Jacobs University in Bremen have just published their cutting-edge research demonstrating advancement in detection of a certain type of immune cells, called T cells. Improved detection of T cells have several therapeutic implications. For example, in cancer immunotherapy (a therapeutic approach that engage patients own immune cells) characterization of […]

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Study links progenitor cells to age-related prostate growth: As the organ enlarges, the risk for cancer and other diseases increases

The prostates of older mice contain more luminal progenitor cells — cells capable of generating new prostate tissue — than the prostates of younger mice, UCLA researchers have discovered. The observation, published in Cell Reports, helps explain why, as people age, the prostate tends to grow, leading to an increased risk for prostate cancer and other conditions. “Understanding what’s causing […]

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Researchers unlock cancer cells’ feeding mechanism, central to tumor growth: The findings could lead to new treatments by blocking tumor growth at its roots

An international team led by researchers from the University of Cincinnati and Japan’s Keio and Hiroshima universities has discovered the energy production mechanism of cancerous cells that drives the growth of the nucleolus and causes tumors to rapidly multiply. The findings, published Aug. 1 in the journal Nature Cell Biology, could lead to the development of new cancer treatments that […]

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Evidence a cancer drug may be extended to many more patients

A new molecular mechanism discovered by UT Southwestern researchers indicates that drugs currently used to treat less than 10 percent of breast cancer patients could have broader effectiveness in treating all cancers where the drugs are used, including ovarian and prostate cancers. The new study also revealed a potential biomarker indicating when these drugs, called PARP inhibitors, can be unleashed […]

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New insight into microRNA function can give gene therapy a boost

Scientists at the University of Eastern Finland and the University of Oxford have shown that small RNA molecules occurring naturally in cells, i.e. microRNAs, are also abundant in cell nuclei. Previously, microRNAs were mainly thought to be found in cytoplasm. The scientists also discovered that microRNA concentrations in cell nuclei change as a result of hypoxia. The findings strongly suggest […]

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