Scientists reverse aging process in rat brain stem cells

New research, published today in Nature, reveals how increasing brain stiffness as we age causes brain stem cell dysfunction, and demonstrates new ways to reverse older stem cells to a younger, healthier state. The results have far reaching implications for how we understand the ageing process, and how we might develop much-needed treatments for age-related brain diseases. As our bodies […]

Read more

Pinpointing how cells regulate long-lasting memories

The brain has a knack for safekeeping our most treasured memories, from a first kiss to a child’s birth. In a new study in mouse cells, Columbia neuroscientists have mapped some of the molecular machinery that helps the brain maintain these kinds of long-term memories. By observing the activity of nerve cells of the brain, called neurons, that were extracted […]

Read more

Dizziness of unknown cause may be perception disorder: Perception disorders may throw those affected off balance

Many patients with functional dizziness look back on a long odyssey to numerous doctors, because no organic causes could be found. Now for the first time, an experiment at the Technical University of Munich (TUM) has identified possible causes of the disorder: problems with the processing of sensory-motor signals in the brain that resemble those associated with dizziness due to […]

Read more

Faulty brain circuits repaired using nanotechnology: Possible new drug targets for dementia and intellectual disability

Working with mouse and human tissue, Johns Hopkins Medicine researchers report new evidence that a protein pumped out of some — but not all — populations of “helper” cells in the brain, called astrocytes, plays a specific role in directing the formation of connections among neurons needed for learning and forming new memories. Using mice genetically engineered and bred with […]

Read more

Exploring genetic ‘dark matter,’ researchers gain new insights into autism and stroke

With its elegant double helix and voluminous genetic script, DNA has become the of darling of nucleic acids. Yet, it is not all powerful. In order for DNA to realize its potential — for genes to become proteins — it must first be transcribed into RNA, a delicate molecule that requires intense care and guidance. “Gene expression is a lot […]

Read more

When a fix for one vision problem causes another

As we age, our eyes lose their ability to focus up close. It’s a condition called presbyopia, and it’s both extremely common and relatively easy to fix, with solutions like reading glasses, bifocals, or progressive lenses. Another common correction, called monovision, solves the problem with different lenses in each eye, one that focuses nearby, the other that focuses far away. […]

Read more

Certain cells secrete a substance in the brain that protects neurons: Finding helps explain cascade of events leading to neurodegeneration

USC researchers have discovered a secret sauce in the brain’s vascular system that preserves the neurons needed to keep dementia and other diseases at bay. The finding, in a mouse model of the human brain, focuses on specific cells called pericytes and reveals that they play a previously unknown role in brain health. Pericytes secrete a substance that keeps neurons […]

Read more

Breaking down pathological protein aggregates

Aggregates of the protein alpha-synuclein in the nerve cells of the brain play a key role in Parkinson’s and other neurodegenerative diseases. These protein clumps can travel from nerve cell to nerve cell, causing the disease to progress. A team of researchers led by ETH scientists have now discovered how the body can rid itself of these damaging aggregates. Their […]

Read more

Which brain hemorrhage patients have treatable underlying conditions

When blood vessels in the brain rupture, or hemorrhage, and cause a stroke, large areas of the brain can be permanently damaged. Depending on the cause, some brain hemorrhages may hide underlying lesions that can be treated with surgery, embolization, radiation, or other treatments. Using MRI scans of patients diagnosed with intracerebral hemorrhage, clinical researchers at Jefferson have teased apart […]

Read more

Drug can reverse hyperactivity induced by parasitic infection

When rodents get infected by Toxoplasma gondii, the single-celled brain parasite that causes toxoplasmosis, they become hyperactive risk-takers. In findings published this week in mBio, researchers show for the first time that it’s possible to reverse that behavioral change. Surprisingly, the study also showed that the restoration of normal behavior resulted from reducing inflammation — and not from reducing the […]

Read more
1 2 3