New microscopes unravel the mysteries of brain organization: Researchers around the world share their stunning images and insights: The open source mesoSPIM Initiative

The secret of capturing exquisite brain images with a new generation of custom-built microscopes is revealed today in Nature Methods. The new microscopes, known as mesoSPIMs, can image the minute detail of brain tissue down to individual neurons that are five times thinner than a human hair, and can uncover the 3D anatomy of entire small organs, faster than ever […]

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For patients with diabetes, ticagrelor reduced heart attacks, strokes: Benefits particularly favorable in patients with prior coronary artery stenting; patients also experienced increased risk of bleeding

In late-breaking clinical trial results presented in a Hot Line Session today at the European Society of Cardiology Congress 2019, investigators from Brigham and Women’s Hospital and Greater Paris University Hospitals — AP-HP/Université de Paris presented the results from The Effect of Ticagrelor on Health Outcomes in Diabetes Mellitus Patients Intervention Study (THEMIS), a clinical trial sponsored by AstraZeneca that […]

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Scientists reverse aging process in rat brain stem cells

New research, published today in Nature, reveals how increasing brain stiffness as we age causes brain stem cell dysfunction, and demonstrates new ways to reverse older stem cells to a younger, healthier state. The results have far reaching implications for how we understand the ageing process, and how we might develop much-needed treatments for age-related brain diseases. As our bodies […]

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Faulty brain circuits repaired using nanotechnology: Possible new drug targets for dementia and intellectual disability

Working with mouse and human tissue, Johns Hopkins Medicine researchers report new evidence that a protein pumped out of some — but not all — populations of “helper” cells in the brain, called astrocytes, plays a specific role in directing the formation of connections among neurons needed for learning and forming new memories. Using mice genetically engineered and bred with […]

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Which brain hemorrhage patients have treatable underlying conditions

When blood vessels in the brain rupture, or hemorrhage, and cause a stroke, large areas of the brain can be permanently damaged. Depending on the cause, some brain hemorrhages may hide underlying lesions that can be treated with surgery, embolization, radiation, or other treatments. Using MRI scans of patients diagnosed with intracerebral hemorrhage, clinical researchers at Jefferson have teased apart […]

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Seeing disfigured faces prompts negative brain and behavior responses: Brain imaging study finds negative implicit biases against individuals with scars, birthmarks and other facial differences

People with attractive faces are often seen as more trustworthy, socially competent, better adjusted, and more capable in school and work. The correlation of attractiveness and positive character traits leads to a “beautiful is good” stereotype. However, little has been understood about the behavioral and neural responses to those with facial abnormalities, such as scars, skin cancers, birthmarks, and other […]

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Automatic neurological disease diagnosis using deep learning: Analyzing brain waveforms using neuroimaging big data helps improve diagnosis accuracy

A team of researchers from Osaka University and The University of Tokyo developed MNet, an automatic diagnosis system for neurological diseases using magnetoencephalography (MEG) , demonstrating the possibility of making automatic neurological disease diagnoses using MEG. Their research results were published in Scientific Reports. MEG and electroencephalography (EEG) are essential for diagnosing neurological diseases such as epilepsy. MEG allows for […]

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Breastfeeding boosts metabolites important for brain growth

Micro-preemies who primarily consume breast milk have significantly higher levels of metabolites important for brain growth and development, according to sophisticated imaging conducted by an interdisciplinary research team at Children’s National. “Our previous research established that vulnerable preterm infants who are fed breast milk early in life have improved brain growth and neurodevelopmental outcomes. It was unclear what makes breastfeeding […]

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New insight into how obesity, insulin resistance can impair cognition

Obesity can break down our protective blood brain barrier resulting in problems with learning and memory, scientists report. They knew that chronic activation of the receptor Adora2a on the endothelial cells that line this important barrier in our brain can let factors from the blood enter the brain and affect the function of our neurons. Now Medical College of Georgia […]

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Neuron and synapse-mimetic spintronics devices developed

A research group from Tohoku University has developed spintronics devices which are promising for future energy-efficient and adoptive computing systems, as they behave like neurons and synapses in the human brain. Today’s information society is built on digital computers that have evolved drastically for half a century and are capable of executing complicated tasks reliably. The human brain, by contrast, […]

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