Microbes on explanted pedicle screws: Possible cause of spinal implant failure

Pedicle screws are often used to secure surgically implanted hardware to the spine in patients with spinal disease or spinal trauma. In some cases, these screws loosen over time, leading to spinal instability and consequent pain. This is a common complication of spine surgery. One reason suggested for pedicle screw loosening is implant-associated infection, but until now there has been […]

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Research implicates causative genes in osteoporosis, suggesting new targets for future therapy: Innovative functional genomics tools likely to aid discovery in other genetic diseases

Scientists have harnessed powerful data analysis tools and three-dimensional studies of genomic geography to implicate new risk genes for osteoporosis, the chronic bone-weakening condition that affects millions of people. Knowing the causative genes may later open the door to more effective treatments. “Identifying a disease’s actual underlying cause often helps to steer us toward correct, targeted treatments,” said study leader […]

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Specific cognitive deficits in individuals with spinal cord injury

A multidisciplinary team of researchers has identified specific cognitive deficits in individuals with spinal cord injury (SCI). Their findings support the theory of accelerated aging after SCI, and have important implications for further research. The article, “Patterns of cognitive deficits in persons with spinal cord injury as compared with both age-matched and older individuals without spinal cord injury,” was e-published […]

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