Typhoid toxin accelerates cell aging to enhance killer infection

Scientists have revealed how the typhoid toxin works to hijack DNA repair machines and accelerate the aging of cells, a breakthrough that could pave the way for new strategies to combat the killer disease. As part of the study, experts from the Department of Biomedical Science with support from the new Healthy Lifespan Institute at the University of Sheffield, infected […]

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On the way to fighting staph infections with the body’s immune system

Researchers have gained a greater understanding of the biology of staphylococcus skin infections in mice and how the mouse immune system mobilizes to fight them. A study appears this week in the Proceedings of the National Academy of Sciences. Community acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) typically causes skin infections but can spread throughout the body to cause invasive infections such […]

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Chemical modifiers tag-team to regulate essential mechanism of life: Basic science discovery explains a fundamental way human cells differ from yeast cells

Scientists at the Gladstone Institutes have made a key observation about one of the most fundamental biological processes: gene transcription. A gene’s job is to provide a cell with the instructions to create a specific protein. The first step of this process is called transcription, during which the DNA is copied into RNA. The scribe is an enzyme called RNA […]

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Structure of the molecular machine that links carbohydrate and lipid metabolism

A research team led by dr. Kenneth Verstraete in the Unit for Structural Biology at the VIB-UGent Center for Inflammation Research has unraveled the three-dimensional structure and molecular mechanism of ATP citrate lyase (ACLY). This is a central metabolic enzyme — a protein that accelerates chemical reactions — important for the production of fatty acids and cholesterol in the human […]

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